Computational modelling for dry-powder inhalers

Ralf Kröger; Robert Woolhouse; Michael Becker; Herbert Wachtel; Anne de Boer; Marc Horner

Computational modelling for dry-powder inhalers

Ralf Kröger
, Robert Woolhouse
, Michael Becker
, Herbert Wachtel
, Anne de Boer
, Marc Horner

Farmaceutische Technologie en Biofarmacie

Onderzoeksoutput › Academic › peer review

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Computational fluid dynamics (CFD) is a simulation tool used for modelling powder flow through inhalers to allow optimisation both of device design and drug powder. Here, Ralf Kröger, Consulting Senior CFD Engineer, ANSYS Germany GmbH; Marc Horner, Lead Technical Services Engineer, Healthcare, ANSYS, Inc; Robert Woolhouse, Senior CFD Engineer, ANSYS UK, Ltd; Michael Becker, PhD Student, and Herbert Wachtel, Senior Principal Scientist, both of Boehringer Ingelheim Pharma GmbH & Co KG; and Anne De Boer, Research Leader Inhalation, University of Groningen, Groningen, The Netherlands, describe in detail how CFD was used in the optimisation of the TwincerTM dry-powder inhaler, extensions of current particle modelling physics to account for particle-particle interactions, and the benefits of this approach in product development. © 2012 Frederick Furness Publishing.

Originele taal-2	English
Pagina's (van-tot)	30-33
Aantal pagina's	4
Tijdschrift	ONdrugDelivery
Nummer van het tijdschrift	APRIL
Status	Published - 1-apr.-2012

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@article{2167039652d04cd6a1a7646bd616c410,

title = "Computational modelling for dry-powder inhalers",

abstract = "Computational fluid dynamics (CFD) is a simulation tool used for modelling powder flow through inhalers to allow optimisation both of device design and drug powder. Here, Ralf Kr{\"o}ger, Consulting Senior CFD Engineer, ANSYS Germany GmbH; Marc Horner, Lead Technical Services Engineer, Healthcare, ANSYS, Inc; Robert Woolhouse, Senior CFD Engineer, ANSYS UK, Ltd; Michael Becker, PhD Student, and Herbert Wachtel, Senior Principal Scientist, both of Boehringer Ingelheim Pharma GmbH \& Co KG; and Anne De Boer, Research Leader Inhalation, University of Groningen, Groningen, The Netherlands, describe in detail how CFD was used in the optimisation of the TwincerTM dry-powder inhaler, extensions of current particle modelling physics to account for particle-particle interactions, and the benefits of this approach in product development. {\textcopyright} 2012 Frederick Furness Publishing.",

keywords = "antibiotic agent, chlorofluorocarbon, colistimethate, propellant, aerosol, airflow, article, computational fluid dynamics, cystic fibrosis, drug industry, geometry, heat transfer, human, inhalation, metered dose inhaler, nebulizer, powder inhaler, respiratory system, spray drying, tuberculosis",

author = "Ralf Kr{\"o}ger and Robert Woolhouse and Michael Becker and Herbert Wachtel and \{de Boer\}, Anne and Marc Horner",

year = "2012",

month = apr,

day = "1",

language = "English",

pages = "30--33",

journal = "ONdrugDelivery",

issn = "2049-1468",

number = "APRIL",

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TY - JOUR

T1 - Computational modelling for dry-powder inhalers

AU - Kröger, Ralf

AU - Woolhouse, Robert

AU - Becker, Michael

AU - Wachtel, Herbert

AU - de Boer, Anne

AU - Horner, Marc

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Computational fluid dynamics (CFD) is a simulation tool used for modelling powder flow through inhalers to allow optimisation both of device design and drug powder. Here, Ralf Kröger, Consulting Senior CFD Engineer, ANSYS Germany GmbH; Marc Horner, Lead Technical Services Engineer, Healthcare, ANSYS, Inc; Robert Woolhouse, Senior CFD Engineer, ANSYS UK, Ltd; Michael Becker, PhD Student, and Herbert Wachtel, Senior Principal Scientist, both of Boehringer Ingelheim Pharma GmbH & Co KG; and Anne De Boer, Research Leader Inhalation, University of Groningen, Groningen, The Netherlands, describe in detail how CFD was used in the optimisation of the TwincerTM dry-powder inhaler, extensions of current particle modelling physics to account for particle-particle interactions, and the benefits of this approach in product development. © 2012 Frederick Furness Publishing.

AB - Computational fluid dynamics (CFD) is a simulation tool used for modelling powder flow through inhalers to allow optimisation both of device design and drug powder. Here, Ralf Kröger, Consulting Senior CFD Engineer, ANSYS Germany GmbH; Marc Horner, Lead Technical Services Engineer, Healthcare, ANSYS, Inc; Robert Woolhouse, Senior CFD Engineer, ANSYS UK, Ltd; Michael Becker, PhD Student, and Herbert Wachtel, Senior Principal Scientist, both of Boehringer Ingelheim Pharma GmbH & Co KG; and Anne De Boer, Research Leader Inhalation, University of Groningen, Groningen, The Netherlands, describe in detail how CFD was used in the optimisation of the TwincerTM dry-powder inhaler, extensions of current particle modelling physics to account for particle-particle interactions, and the benefits of this approach in product development. © 2012 Frederick Furness Publishing.

KW - antibiotic agent

KW - chlorofluorocarbon

KW - colistimethate

KW - propellant

KW - aerosol

KW - airflow

KW - article

KW - computational fluid dynamics

KW - cystic fibrosis

KW - drug industry

KW - geometry

KW - heat transfer

KW - human

KW - inhalation

KW - metered dose inhaler

KW - nebulizer

KW - powder inhaler

KW - respiratory system

KW - spray drying

KW - tuberculosis

M3 - Article

SN - 2049-1468

SP - 30

EP - 33

JO - ONdrugDelivery

JF - ONdrugDelivery

IS - APRIL

ER -

Computational modelling for dry-powder inhalers

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