Samenvatting
A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford diverse α-isocyano-ω-amines. In the second step, the α-isocyano-ω-amines undergo an Ugi tetrazole reaction to close the macrocycle. Advantageously, this strategy allows short access to 11-19-membered macrocycles in which substituents can be independently varied at three different positions.
Originele taal-2 | English |
---|---|
Pagina's (van-tot) | 5078-5081 |
Aantal pagina's | 4 |
Tijdschrift | Organic letters |
Volume | 19 |
DOI's | |
Status | Published - 13-sep.-2017 |
Datasets
-
CCDC 1548701: Experimental Crystal Structure Determination
Abdelraheem, E. (Contributor), Haan , de, M. (Contributor), Patil, P. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłuścik, J. (Contributor), Shaabani, S. (Contributor) & Dömling, A. (Contributor), University of Groningen, 8-mei-2017
DOI: 10.5517/ccdc.csd.cc1nzk39
Dataset
-
CCDC 1548704: Experimental Crystal Structure Determination
Abdelraheem, E. (Contributor), Haan , de, M. (Contributor), Patil, P. (Contributor), Kurpiewska, K. (Contributor), Kalinowska-Tłuścik, J. (Contributor), Shaabani, S. (Contributor) & Dömling, A. (Contributor), University of Groningen, 8-mei-2017
DOI: 10.5517/ccdc.csd.cc1nzk6d
Dataset