Continuous chiral separations in microreactors

Susanti Susanti; Tim G. Meinds; Erik Pinxterhuis; Boelo Schuur; Johannes G. de Vries; B.L. Feringa; Jozef Winkelman; Jun Yue; Hero Heeres

Continuous chiral separations in microreactors

Susanti Susanti, Tim G. Meinds, Erik Pinxterhuis, Boelo Schuur, Johannes G. de Vries, B.L. Feringa, Jozef Winkelman, Jun Yue, Hero Heeres

Onderzoeksoutput › Academic

Samenvatting

The potential of microreactors for enantioselective liquid-liquid extraction has been explored. The experiments were performed in capillary microreactors with combined reactive extraction and phase separation, for the chiral separation of a representative racemic amino acid derivative (3,5-R,S-DNBLeu) dissolved in water by using a chiral host (a chinchona alkaloid) in the organic phase (1-octanol
or 1,2-DCE). The results show that the ee is higher at short residence times of the two liquid phases in comparison with the ee at equilibrium. The performance and advantages of microreator operation in chiral separation will be further discussed.

Originele taal-2	English
Status	Published - 1-dec-2016
Evenement	CHAINS 2016 - Veldhoven, Netherlands Duur: 6-dec-2016 → 8-dec-2016

Conference

Conference	CHAINS 2016
Land/Regio	Netherlands
Stad	Veldhoven
Periode	06/12/2016 → 08/12/2016

Citeer dit

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title = "Continuous chiral separations in microreactors",

abstract = "The potential of microreactors for enantioselective liquid-liquid extraction has been explored. The experiments were performed in capillary microreactors with combined reactive extraction and phase separation, for the chiral separation of a representative racemic amino acid derivative (3,5-R,S-DNBLeu) dissolved in water by using a chiral host (a chinchona alkaloid) in the organic phase (1-octanolor 1,2-DCE). The results show that the ee is higher at short residence times of the two liquid phases in comparison with the ee at equilibrium. The performance and advantages of microreator operation in chiral separation will be further discussed.",

author = "Susanti Susanti and Meinds, {Tim G.} and Erik Pinxterhuis and Boelo Schuur and {de Vries}, {Johannes G.} and B.L. Feringa and Jozef Winkelman and Jun Yue and Hero Heeres",

year = "2016",

month = dec,

day = "1",

language = "English",

note = "CHAINS 2016 ; Conference date: 06-12-2016 Through 08-12-2016",

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TY - CONF

T1 - Continuous chiral separations in microreactors

AU - Susanti, Susanti

AU - Meinds, Tim G.

AU - Pinxterhuis, Erik

AU - Schuur, Boelo

AU - de Vries, Johannes G.

AU - Feringa, B.L.

AU - Winkelman, Jozef

AU - Yue, Jun

AU - Heeres, Hero

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The potential of microreactors for enantioselective liquid-liquid extraction has been explored. The experiments were performed in capillary microreactors with combined reactive extraction and phase separation, for the chiral separation of a representative racemic amino acid derivative (3,5-R,S-DNBLeu) dissolved in water by using a chiral host (a chinchona alkaloid) in the organic phase (1-octanolor 1,2-DCE). The results show that the ee is higher at short residence times of the two liquid phases in comparison with the ee at equilibrium. The performance and advantages of microreator operation in chiral separation will be further discussed.

AB - The potential of microreactors for enantioselective liquid-liquid extraction has been explored. The experiments were performed in capillary microreactors with combined reactive extraction and phase separation, for the chiral separation of a representative racemic amino acid derivative (3,5-R,S-DNBLeu) dissolved in water by using a chiral host (a chinchona alkaloid) in the organic phase (1-octanolor 1,2-DCE). The results show that the ee is higher at short residence times of the two liquid phases in comparison with the ee at equilibrium. The performance and advantages of microreator operation in chiral separation will be further discussed.

M3 - Abstract

T2 - CHAINS 2016

Y2 - 6 December 2016 through 8 December 2016

ER -