TY - JOUR
T1 - Contributions of Interactions Between Lifestyle and Genetics on Coronary Artery Disease Risk
AU - Said, M Abdullah
AU - van de Vegte, Yordi J
AU - Zafar, Muhammad Mobeen
AU - van der Ende, M Yldau
AU - Raja, Ghazala Kaukab
AU - Verweij, N
AU - van der Harst, Pim
PY - 2019/9
Y1 - 2019/9
N2 - PURPOSE OF THE REVIEW: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.RECENT FINDINGS: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.
AB - PURPOSE OF THE REVIEW: To summarize current knowledge on interactions between genetic variants and lifestyle factors (G×L) associated with the development of coronary artery disease (CAD) and prioritize future research.RECENT FINDINGS: Genetic risk and combined lifestyle factors and behaviors have a log-additive effect on the risk of developing CAD. First, we describe genetic and lifestyle factors associated with CAD and then focus on G×L interactions. The majority of G×L interaction studies are small-scale candidate gene studies that lack replication and therefore provide spurious results. Only a few studies, of which most use genetic risk scores or genome-wide approaches to test interactions, are robust in number and analysis strategy. These studies provide evidence for the existence of G×L interactions in the development of CAD. Further G×L interactions studies are important as they contribute to our understanding of disease pathophysiology and possibly provide insights for improving interventions or personalized recommendations.
KW - Genetics
KW - Lifestyle
KW - Coronary artery disease
KW - Genetic lifestyle interactions
KW - Genome-wide association studies
KW - Genetic risk scores
KW - DOSE-RESPONSE METAANALYSIS
KW - TERM COFFEE CONSUMPTION
KW - HEART-DISEASE
KW - CARDIOVASCULAR-DISEASE
KW - PHYSICAL-ACTIVITY
KW - MYOCARDIAL-INFARCTION
KW - ALCOHOL-CONSUMPTION
KW - CIGARETTE-SMOKING
KW - ASSOCIATION
KW - INDIVIDUALS
U2 - 10.1007/s11886-019-1177-x
DO - 10.1007/s11886-019-1177-x
M3 - Review article
C2 - 31352625
VL - 21
SP - 89
JO - Current cardiology reports
JF - Current cardiology reports
SN - 1523-3782
IS - 9
M1 - 89
ER -