Controlling miRNA regulation in disease

Willemijn M. Gommans, Eugene Berezikov*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ChapterAcademicpeer review

29 Citaten (Scopus)

Samenvatting

Our understanding of the importance of noncoding RNA molecules is steadily growing. One such important class of RNA molecules are microRNAs (miRNAs). These tiny RNAs fulfill important functions in cellular behavior by influencing the protein output levels of a high variety of genes through the regulation of target messenger RNAs. Moreover, miRNAs have been implicated in a wide range of diseases. In pathological conditions, the miRNA expression levels can be altered due to changes in the transcriptional or posttranscriptional regulation of miRNA expression. On the other side, mRNA molecules might be able to escape the regulation by miRNAs. In this review, we give an overview on how miRNA biogenesis can be altered in disease as well as how mRNAs can avoid the regulation by miRNAs. The interplay between these two processes defines the final protein output in a cell, and thus the normal or pathological cellular phenotype.

Originele taal-2English
TitelNext-Generation MicroRNA Expression Profiling Technology
SubtitelMethods and Protocols
RedacteurenJian-Bing Fan
Pagina's1-18
Aantal pagina's18
DOI's
StatusPublished - 23-jan-2012

Publicatie series

NaamMethods in Molecular Biology
Volume822
ISSN van geprinte versie1064-3745

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