Controlling the activity of quorum sensing autoinducers with light

J. P. Van der Berg, W. A. Velema, W. Szymanski, A. J. M. Driessen*, B. L. Feringa

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

24 Citaten (Scopus)
262 Downloads (Pure)

Samenvatting

Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa.

Originele taal-2English
Pagina's (van-tot)3593-3598
Aantal pagina's6
TijdschriftChemical Science
Volume6
Nummer van het tijdschrift6
DOI's
StatusPublished - 2015

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