COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins

OnderzoeksoutputAcademicpeer review

3 Citaten (Scopus)
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Samenvatting

COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP). We aimed to determine the SASP of senescent fibroblasts and COPD-derived lung fibroblasts, including severe, early-onset (SEO)-COPD. SASP protein secretion was measured after paraquat-induced senescence in lung fibroblasts using Olink Proteomics and compared between (SEO-)COPD-derived and control-derived fibroblasts. We identified 124 SASP proteins of senescent lung fibroblasts, of which 42 were secreted at higher levels by COPD-derived fibroblasts and 35 by SEO-COPD-derived fibroblasts compared with controls. Interestingly, the (SEO-)COPD-associated SASP included proteins involved in chronic inflammation, which may contribute to (SEO-)COPD pathogenesis.

Originele taal-2English
Pagina's (van-tot)508-511
Aantal pagina's4
TijdschriftThorax
Volume76
Nummer van het tijdschrift5
Vroegere onlinedatum3-dec-2020
DOI's
StatusPublished - mei-2021

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