TY - JOUR
T1 - Correction: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (vol 49, pg 403, 2017)
AU - Warren, Helen R.
AU - Evangelou, Evangelos
AU - Cabrera, Claudia P.
AU - Gao, He
AU - Ren, Meixia
AU - Mifsud, Borbala
AU - Ntalla, Ioanna
AU - Surendran, Praveen
AU - Liu, Chunyu
AU - Cook, James P.
AU - Kraja, Aldi T.
AU - Drenos, Fotios
AU - Loh, Marie
AU - Verweij, Niek
AU - Marten, Jonathan
AU - Karaman, Ibrahim
AU - Lepe, Marcelo P. Segura
AU - O'Reilly, Paul F.
AU - Knight, Joanne
AU - Snieder, Harold
AU - Kato, Norihiro
AU - He, Jiang
AU - Tai, E. Shyong
AU - Said, M. Abdullah
AU - Porteous, David
AU - Alver, Maris
AU - Poulter, Neil
AU - Farrall, Martin
AU - Gansevoort, Ron T.
AU - Padmanabhan, Sandosh
AU - Magi, Reedik
AU - Stanton, Alice
AU - Connell, John
AU - Bakker, Stephan J. L.
AU - Metspalu, Andres
AU - Shields, Denis C.
AU - van der Harst, Pim
AU - Vaez, Ahmad
AU - van der Most, Peter J.
AU - Nolte, Ilja M.
AU - de Borst, Martin H.
AU - Damman, Jeffrey J.
AU - Oldehinkel, Albertine J.
AU - Penninx, Brenda W. J. H.
AU - Riese, Harriette
AU - Seelen, Marc A.
AU - Swertz, Morris
AU - van der Harst, Pim
AU - Hartman, Catharina A.
AU - Snieder, Harold
AU - Int Consortium Blood Pressure ICBP
AU - CHD Exome Consortium
AU - ExomeBP Consortium
AU - T2D-GENES Consortium
AU - GoT2D Genes Consortium
AU - CHARGE BP Exome Consortium
AU - iGEN-BP Consortium
AU - UK Biobank CardioMetab Consortium
AU - BIOS Consortium
AU - Lifelines Cohort Study
AU - Understanding Soc Sci Grp
PY - 2017/10
Y1 - 2017/10
N2 - Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.
AB - Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. In combination with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure–raising genetic variants on future cardiovascular disease risk.
KW - CORONARY-ARTERY-DISEASE
KW - ENDOTHELIAL-CELL
KW - MYOCARDIAL-INFARCTION
KW - NEUROTROPHIC FACTOR
KW - NADPH OXIDASE
KW - UK BIOBANK
KW - KEY ROLE
KW - IN-VIVO
KW - HYPERTENSION
KW - COMMON
U2 - 10.1038/ng.3768
DO - 10.1038/ng.3768
M3 - Erratum
C2 - 28135244
SN - 1061-4036
VL - 49
SP - 403
EP - 415
JO - Nature Genetics
JF - Nature Genetics
IS - 3
ER -