Correlation of proton MR spectroscopy and diffusion tensor imaging

R Irwan*, PE Sijens, JH Potze, M Oudkerk

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    25 Citaten (Scopus)


    Proton magnetic resonance spectroscopy (H-1-MRS) provides indices of neuronal damage. Diffusion tensor imaging (DTI) relates to water diffusivity and fiber tract orientation. A method to compare H-1-MRS and DTI findings was developed, tested on phantom and applied on normal brain. Point-resolved spectroscopy (T-R/T-E = 1500/135) was used for chemical shift imaging of a supraventricular volume of interest of 8x8x2 cm(3) (64 voxels). In DTI, a segmental spin-echo sequence (T-R/T-E = 5500/91) was used and slices were stacked to reproduce the slab used in MRS.

    The spatial distributions of choline and N-acetylaspartate (NAA) correlated to mean fractional anisotropy and apparent diffusion coefficient (ADC) for the inner 6x6 = 36 voxels defined in MRS, most notably NAA and ADC value (r = -.70, P

    Originele taal-2English
    Pagina's (van-tot)851-858
    Aantal pagina's8
    TijdschriftMagnetic Resonance Imaging
    Nummer van het tijdschrift8
    StatusPublished - okt.-2005

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