Corticosteroid hormones, synaptic strength and emotional memories: Corticosteroid modulation of memory - a cellular and molecular perspective

Olof Wiegert*, Marian Joels, Harm J. Krugers

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

10 Citaten (Scopus)

Samenvatting

Emotionally loaded and stressful events modulate cognitive performance. This modulation of cognitive performance is at least partially dependent on corticosteroid hormones that are released in high amounts during emotional or stressful events. Corticosterone both strengthens and suppresses cognitive performance and synaptic plasticity. These effects may critically depend on the timing of the stressful event and corticosteroid exposure with respect to the learning situation. Based on recent findings we propose a model in which corticosterone can rapidly enhance synaptic plasticity. Later, corticosterone may stabilize synaptic efficacy, possibly at the expense of reduced synaptic plasticity.

Originele taal-2English
TitelSTRESS HORMONES AND POST TRAUMATIC STRESS DISORDER: BASIC STUDIES AND CLINICAL PERSPECTIVES
RedacteurenER DeKloet, E Vermetten
UitgeverijELSEVIER SCIENCE BV
Pagina's269-271
Aantal pagina's3
ISBN van geprinte versie978-0-444-53140-7
DOI's
StatusPublished - 2007
Extern gepubliceerdJa
EvenementColloquium on Stress Hormones and Post Traumatic Stress Disorder - Basic Studies and Clinical Perspectives - Amsterdam, Netherlands
Duur: 28-aug.-200630-aug.-2006

Publicatie series

NaamProgress in Brain Research
UitgeverijELSEVIER SCIENCE BV
Volume167
ISSN van geprinte versie0079-6123

Conference

ConferenceColloquium on Stress Hormones and Post Traumatic Stress Disorder - Basic Studies and Clinical Perspectives
Land/RegioNetherlands
StadAmsterdam
Periode28/08/200630/08/2006

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