Corticosterone modifies muscarinic receptor immunoreactivity in rat hippocampus

B R K Douma, K Jansen, S M Korte, B Buwalda, E A Van der Zee, P G M Luiten

OnderzoeksoutputAcademicpeer review

5 Citaten (Scopus)


In the present study we report the effect of corticosterone in the regulation of hippocampal muscarinic acetylcholine receptor immunoreactivity (mAChR-ir) expression in rats. Adrenalectomy (ADX) or a single injection of a mineralocorticoid antagonist RU-28318 (1.0 mg/100 g body weight (b.w.)) in adrenally intact rats 24 h prior to sacrifice revealed an increased mAChR-ir in hippocampal CA1 and CA3 areas. Corticosterone replacement (100 mu g/100 g b.w.) prevented the increase in mAChR-ir of ADX animals. However, glucocorticoid receptor antagonist (RU38486) treatment in adrenally intact rats failed to affect the mAChR immunolabeling, These results point to a modulation of muscarinic receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)41-44
Aantal pagina's4
TijdschriftNeuroscience Letters
Nummer van het tijdschrift1
StatusPublished - 11-jun-1999

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