Critical Data-Based Re-Evaluation of Minocycline as a Putative Specific Microglia Inhibitor

Thomas Moller*, Frederique Bard, Anindya Bhattacharya, Knut Biber, Brian Campbell, Elena Dale, Claudia Eder, Li Gan, Gwenn A. Garden, Zoe A. Hughes, Damien D. Pearse, Roland G. W. Staal, Faten A. Sayed, Paul D. Wes, Hendrikus W. G. M. Boddeke

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

89 Citaten (Scopus)

Samenvatting

Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted.

Originele taal-2English
Pagina's (van-tot)1788-1794
Aantal pagina's7
TijdschriftGlia
Volume64
Nummer van het tijdschrift10
DOI's
StatusPublished - okt-2016

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