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The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for positron emission tomography (PET) is presented. The radiolabelled products were obtained in excellent yields, at rt and after short reaction times (3-5 min) compatible with the half-life of 11C (20.4 min). The automation of the protocol on a synthesis module is investigated, representing an important step towards a fast method for the synthesis of 11C-labelled compounds for PET imaging.

Originele taal-2English
Pagina's (van-tot)203-206
Aantal pagina's4
TijdschriftChemical communications (Cambridge, England)
Nummer van het tijdschrift2
Vroegere onlinedatum26-dec.-2020
StatusPublished - 7-jan.-2021

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