Samenvatting
PnuC transporters catalyze cellular uptake of the NAD(+) precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3 + 1 + 3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.
Originele taal-2 | English |
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Pagina's (van-tot) | 1013-1015 |
Aantal pagina's | 3 |
Tijdschrift | Nature Structural & Molecular Biology |
Volume | 21 |
Nummer van het tijdschrift | 11 |
DOI's | |
Status | Published - 7-okt.-2014 |
Vingerafdruk
Duik in de onderzoeksthema's van 'Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog'. Samen vormen ze een unieke vingerafdruk.Pers/Media
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