Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog

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37 Citaten (Scopus)

Samenvatting

PnuC transporters catalyze cellular uptake of the NAD(+) precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3 + 1 + 3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.

Originele taal-2English
Pagina's (van-tot)1013-1015
Aantal pagina's3
TijdschriftNature Structural & Molecular Biology
Volume21
Nummer van het tijdschrift11
DOI's
StatusPublished - 7-okt.-2014

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