Cu(ii)-Catalysed β-silylation of dehydroalanine residues in peptides and proteins

Reinder H de Vries, Gerard Roelfes

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)
36 Downloads (Pure)


We report the efficient and selective Cu(ii)-catalysed β-silylation of naturally occurring dehydroalanine (Dha) residues in various ribosomally synthesized and post-translationally modified peptides (RiPPs). The method is also applicable to proteins, as was shown by the modification of a Dha residue that was chemically introduced into Small Ubiquitin-like Modifier (SUMO).

Originele taal-2English
Pagina's (van-tot)11058-11061
Aantal pagina's4
TijdschriftChemical communications (Cambridge, England)
Nummer van het tijdschrift75
Vroegere onlinedatum19-aug-2020
StatusPublished - 25-sep-2020

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