@inbook{846589112f00492fba012e5f3adbf57e,
title = "D-serine influences synaptogenesis in a p19 cell model",
abstract = "Recently, D-serine has been identified as an important NMDA-receptor co-agonist, which might play a role in central nervous system development. We investigated this by studying rat P19 cells, an established model for neuronal and glial differentiation. Our results show that (1) the D-serine synthesizing enzyme serine racemase was expressed upon differentiation, (2) extracellular D-serine concentrations increased upon differentiation, which was inhibited by serine racemase antagonism, and (3) inhibition of D-serine synthesis or prevention of D-serine binding to the NMDA-receptor increased synaptophysin expression and intercellular connections, supporting a role for NMDA-receptor activation by D-serine, synthesized by serine racemase, in shaping synaptogenesis and neuronal circuitry during central nervous system development. In conjunction with recent evidence from literature, we therefore suggest that D-serine deficiency might be responsible for the severe neurological phenotype seen in patients with serine deficiency disorders. In addition, this may provide a pathophysiological mechanism for a role of D-serine deficiency in psychiatric disorders.",
author = "Fuchs, {Sabine A} and Roeleveld, {Martin W} and Klomp, {Leo W J} and Ruud Berger and {de Koning}, {Tom J}",
year = "2012",
doi = "10.1007/8904_2011_116",
language = "English",
isbn = "978-3-642-28128-0",
volume = "6",
series = "Journal of Inherited Metabolic Disorders",
publisher = "Springer-Verlag Berlin Heidelberg",
pages = "47--53",
editor = "{Society for the Study of Inborn Errors of Metabolism}",
booktitle = "JIMD Reports - Case and Research Reports, 2012/3",
}