Deciphering Physiological Functions of AHL Quorum Quenching Acylases

Putri D. Utari, Jan Vogel, Wim J. Quax*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

25 Citaten (Scopus)
343 Downloads (Pure)

Samenvatting

N-Acylhomoserine lactone (AHL)-acylase (also known as amidase or amidohydrolase) is a class of enzyme that belongs to the Ntn-hydrolase superfamily. As the name implies, AHL-acylases are capable of hydrolysing AHLs, the most studied signaling molecules for quorum sensing in Gram-negative bacteria. Enzymatic degradation of AHLs can be beneficial in attenuating bacterial virulence, which can be exploited as a novel approach to fight infection of human pathogens, phytopathogens or aquaculture-related contaminations. Numerous acylases from both prokaryotic and eukaryotic sources have been characterized and tested for the interference of quorum sensing-regulated functions. The existence of AHL-acylases in a multitude of organisms from various ecological niches, raises the question of what the physiological roles of AHL-acylases actually are. In this review, we attempt to bring together recent studies to extend our understanding of the biological functions of these enzymes in nature.

Originele taal-2English
Artikelnummer1123
Aantal pagina's13
TijdschriftFrontiers in Microbiology
Volume8
DOI's
StatusPublished - 19-jun-2017

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