Decreased impact of post-myocardial infarction depression on cardiac prognosis?

Titia A. Spijkerman, Rob H. S. van den Brink*, Jo F. May, Jobst B. Winter, Joost P. van Melle, Peter de Jonge, Harry J. G. M. Crijns, Johan Ormel

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

28 Citaten (Scopus)


Objective: A recent meta-analysis suggests that the impact of post-myocardial infarction (MI) depression on cardiac prognosis has decreased over the last decade. We tested whether depression still significantly affects prognosis in the present health care situation.

Methods: Four hundred ninety-four MI patients were screened for depression. Patients with depression were compared with patients without on cardiovascular events (fatal or nonfatal) during an average follow-up of 2.5 years. Demographic characteristics and cardiac risk factors were controlled for.

Results: We found that depression was associated with the occurrence of cardiovascular events in both univariate [hazard ratio (HR), 1.84; 95% confidence interval, 1.24-2.72] and multivariate analysis (HR, 1.56; 1.02-2.38).

Conclusions: Depression still has an independent impact on cardiac prognosis after MI, but this influence is smaller than found in early studies. Improvements in general care for MI and better recognition and treatment of post-MI depression may have decreased the impact of depression on prognosis. (c) 2006 Elsevier Inc. All rights reserved.

Originele taal-2English
Pagina's (van-tot)493-499
Aantal pagina's7
TijdschriftJournal of Psychosomatic Research
Nummer van het tijdschrift4
StatusPublished - okt.-2006

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