TY - PAT
T1 - Delivery and measurement of fluorescent nanocrystals in biological tissue
AU - Sigaeva, Alina
AU - Fan, Siyu
AU - Zhang, Yue
AU - Elías Llumbet, Arturo
AU - Dias Carmona Lobita, Maria Margarida
AU - Shahbazi, Mohammad-Ali
AU - Almeida Santos, Hélder
PY - 2024/12/12
Y1 - 2024/12/12
N2 - A microneedle assembly (10) for delivering fluorescent nanocrystals (FNC) into a tissue (T) comprises one or more microneedles (11). Each microneedle (11) comprises a plurality of fluorescent nanocrystals (FNC) dispersed throughout a solid matrix material (11m). The tissue (T) can be penetrated with the one or more microneedles (11) and at least part of the matrix material (11m) can be dissolved inside the tissue for delivering the fluorescent nanocrystals (FNC) into the tissue (T). Various aspects of the tissue (T) can be measured by delivering light pulses to the tissue (T), and measuring a resultant fluorescent signal (Sf) from the fluorescent nanocrystals (FNC) inside the tissue (T). The microneedle assembly (10) can be, for example, manufactured using micro-molding techniques using a liquid precursor of the matrix material (11m) with a concentration of the fluorescent nanocrystals (FNC) in the liquid precursor.
AB - A microneedle assembly (10) for delivering fluorescent nanocrystals (FNC) into a tissue (T) comprises one or more microneedles (11). Each microneedle (11) comprises a plurality of fluorescent nanocrystals (FNC) dispersed throughout a solid matrix material (11m). The tissue (T) can be penetrated with the one or more microneedles (11) and at least part of the matrix material (11m) can be dissolved inside the tissue for delivering the fluorescent nanocrystals (FNC) into the tissue (T). Various aspects of the tissue (T) can be measured by delivering light pulses to the tissue (T), and measuring a resultant fluorescent signal (Sf) from the fluorescent nanocrystals (FNC) inside the tissue (T). The microneedle assembly (10) can be, for example, manufactured using micro-molding techniques using a liquid precursor of the matrix material (11m) with a concentration of the fluorescent nanocrystals (FNC) in the liquid precursor.
M3 - Patent
M1 - WO2024253518
Y2 - 2024/06/04
ER -