TY - JOUR
T1 - Dengue tropism for macrophages and dendritic cells
T2 - the host cell effect
AU - Flipse, Jacky
AU - Torres Pedraza, Silvia
AU - Diosa-Toro, Mayra
AU - van der Ende-Metselaar, Heidi
AU - Herrera-Rodriguez, Jose
AU - Urcuqui-Inchima, Silvio
AU - Huckriede, Anke
AU - Rodenhuis-Zybert, Izabela A
AU - Smit, Jolanda M
PY - 2016/7
Y1 - 2016/7
N2 - Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC derived virus. Taken together, our results highlight the importance of macrophages in dengue infection.
AB - Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC derived virus. Taken together, our results highlight the importance of macrophages in dengue infection.
KW - ANTIBODY-DEPENDENT ENHANCEMENT
KW - VIRUS-INFECTION
KW - TARGET-CELLS
KW - PARTICLES
KW - DISEASE
KW - TISSUES
KW - CLEC5A
KW - ENTRY
U2 - 10.1099/jgv.0.000474
DO - 10.1099/jgv.0.000474
M3 - Article
C2 - 27046075
VL - 97
SP - 1531
EP - 1536
JO - The Journal of general virology
JF - The Journal of general virology
SN - 0022-1317
ER -