Dengue virus life cycle: viral and host factors modulating infectivity

Izabela A. Rodenhuis-Zybert, Jan Wilschut, Jolanda M. Smit*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

248 Citaten (Scopus)


Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world and infect 50-100 million individuals annually. Whereas the majority of DENV infections proceed asymptomatically or result in self-limited dengue fever, an increasing number of patients present more severe manifestations, such as dengue hemorrhagic fever and dengue shock syndrome. In this review we will give an overview of the infectious life cycle of DENV and will discuss the viral and host factors that are important in controlling DENV infection.

Originele taal-2English
Pagina's (van-tot)2773-2786
Aantal pagina's14
TijdschriftCellular and molecular life sciences
Nummer van het tijdschrift16
Vroegere onlinedatum6-apr-2010
StatusPublished - aug-2010

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