Design and modular parallel synthesis of a MCR derived α-helix mimetic protein-protein interaction inhibitor scaffold

Walfrido Antuch, Sanjay Menon, Quin-Zene Chen, Yingchun Lu, Sukumar Sakamuri, Barbara Beck, Vesna Schauer-Vukašinović, Seema Agarwal, Sibylle Hess, Alexander Dömling

OnderzoeksoutputAcademicpeer review

48 Citaten (Scopus)


A terphenyl α-helix mimetic scaffold recognized to be capable of disrupting protein-protein interactions was structurally morphed into an easily amenable and versatile multicomponent reaction (MCR) backbone. The design, modular in-parallel library synthesis, initial cell based biological data, and preliminary in vitro screening for the disruption of the Bcl-w/Bak protein-protein interaction by representatives of the MCR derived scaffold are presented.
Originele taal-2English
Pagina's (van-tot)1740-1743
Aantal pagina's4
TijdschriftBioorganic and Medicinal Chemistry Letters
Nummer van het tijdschrift6
StatusPublished - 15-mrt-2006

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