Design and synthesis of ligands targeting MIF family enzymes and their application in medicinal chemistry

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Samenvatting

This thesis addresses several aspects of the design and synthesis of ligands targeting the macrophage migration inhibitory factor (MIF) proteins family and their application
in medicinal chemistry. The human MIF family in humans consists of MIF, its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2), and the relatively unknown protein named DDT-like (DDTL). In this work we implement new drug design modalities and contribute to the development of therapeutic strategies against cancer and inflammatory diseases. Through thorough literature research, exploration of novel synthetic approaches, structure-activity relationship studies, and cell-based studies, we made a step forward toward understanding the function of MIF family enzymes in cells. Despite no MIF or D-DT targeted drugs being available on the market currently, due to the fact that creating the drug with promising efficacy and safety profile remains challenging, our work demonstrates the potential for future clinical studies in the field.
Originele taal-2English
KwalificatieDoctor of Philosophy
Toekennende instantie
  • Rijksuniversiteit Groningen
Begeleider(s)/adviseur
  • Dekker, Frank, Supervisor
  • Poelarends, Gerrit, Supervisor
Datum van toekenning7-nov.-2023
Plaats van publicatie[Groningen]
Uitgever
Gedrukte ISBN's978-90-833743-2-1
DOI's
StatusPublished - 2023

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