Developing health economic models of chronic diseases for reimbursement purposes

Bartele Marten Sybrens Heeg

doi:10.1016/j.jval.2014.12.008

Developing health economic models of chronic diseases for reimbursement purposes

Vertaalde titel van de bijdrage: Ontwikkelen van gezondheid economische modellen voor vergoedingsdoeleinden

Bartele Marten Sybrens Heeg

Onderzoeksoutput: Thesis fully internal (DIV)

5161 Downloads (Pure)

Samenvatting

De bevolking van Nederland en andere Europese landen vergrijsd. Hierdoor neemt het aantal mensen met chronische ziekten, die vaak chronische medicatie nodig hebben, toe. Nieuwe geneesmiddelen, diagnostische testen en medische hulpmiddelen zijn vaak effectiever dan de tot dan toe beschikbare standaard behandelingen. Ook zijn deze nieuwe gezondheidstechnologieën vaak duurder dan de huidige standaard behandeling. Met behulp van gezondheid economische modellen kunnen deze extra baten tegen de extra kosten afgewogen worden om te bepalen of de nieuwe gezondheidstechnologie doelmatig is en dus vergoed zou moeten worden. Dit proefschrift gaat over de voor en nadelen van verschillende typen gezondheids-economische modellen. Er worden drie toepassingen van modellen voor chronische ziektes gepresenteerd (schizofrenie, cardiovasculair en multipel myeloom). Verder wordt er aandacht besteed aan model parameter schattingen met betrekking tot compliance en categorische variabelen zoals complete, partiele en geen response in multipel myeloom. In het laatste hoofdstuk wordt onderzocht welke gezondheid economische parameters van invloed zijn op de vergoedingsbeslissingen in Schotland.

Vertaalde titel van de bijdrage	Ontwikkelen van gezondheid economische modellen voor vergoedingsdoeleinden
Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Postma, Maarten, Supervisor Buskens, Erik, Supervisor van Hout, Ben A., Supervisor, Externe Persoon
Datum van toekenning	1-mei-2015
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
Gedrukte ISBN's	978-90-367-7777-3
Elektronische ISBN's	978-90-367-7776-6
DOI's	https://doi.org/10.1016/j.jval.2014.12.008
Status	Published - 2015

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10.1016/j.jval.2014.12.008

Title and contentsFinal publisher's version, 84,5 KB
Chapter 1Final publisher's version, 129 KB
Chapter 2Final publisher's version, 1,28 MB
Chapter 3Final publisher's version, 639 KB
Chapter 4Final publisher's version, 554 KB
Chapter 5Final publisher's version, 1,8 MB
Chapter 6Final publisher's version, 703 KB
Chapter 7Final publisher's version, 2,92 MB
Chapter 8Final publisher's version, 677 KB
Chapter 9Final publisher's version, 629 KB
AppendixFinal publisher's version, 510 KB
Complete dissertationFinal publisher's version, 5,87 MB
PropositionsFinal publisher's version, 18,8 KB

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title = "Developing health economic models of chronic diseases for reimbursement purposes",

abstract = "With an ageing population the number of chronic diseases, often requiring chronic treatment, is increasing. New health care technologies, such as drugs, diagnostics and medical devices, often provide an improvement to current standard of care. This improvement obviously comes at a certain cost. In health economics, this added benefit is weighted against the higher costs to determine whether a technology is cost-effective and in the end should be reimbursed. For that purpose, health economic models are used. This thesis deals with health-economic modelling of chronic diseases for reimbursement purposes. In the first part, various modelling approaches are discussed and applications of those approaches presented for three chronic diseases (schizophrenia, cardiovascular disease and multiple myeloma). The second part is on model parameter estimations in terms of (i) incorporating compliance and (ii) various methods of incorporating categorical inputs in health economic models. Finally, the issue of identifying variables (including health economic outcomes), that are predictive for reimbursement decisions in Scotland, is addressed.",

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AB - With an ageing population the number of chronic diseases, often requiring chronic treatment, is increasing. New health care technologies, such as drugs, diagnostics and medical devices, often provide an improvement to current standard of care. This improvement obviously comes at a certain cost. In health economics, this added benefit is weighted against the higher costs to determine whether a technology is cost-effective and in the end should be reimbursed. For that purpose, health economic models are used. This thesis deals with health-economic modelling of chronic diseases for reimbursement purposes. In the first part, various modelling approaches are discussed and applications of those approaches presented for three chronic diseases (schizophrenia, cardiovascular disease and multiple myeloma). The second part is on model parameter estimations in terms of (i) incorporating compliance and (ii) various methods of incorporating categorical inputs in health economic models. Finally, the issue of identifying variables (including health economic outcomes), that are predictive for reimbursement decisions in Scotland, is addressed.

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