Diabetes mellitus and rhegmatogenous retinal detachment: Exploring the role of advanced glycation endproducts in systemic and local disease

Bernardina Teunisje Fokkens

Diabetes mellitus and rhegmatogenous retinal detachment: Exploring the role of advanced glycation endproducts in systemic and local disease

Bernardina Teunisje Fokkens

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Samenvatting

In samenhang met de toenemende levensverwachting van de bevolking stijgt het vóórkomen van
veel leeftijdsgerelateerde ziekten. De vervelende complicaties die gepaard gaan met deze ziekten
hebben een grote invloed op het dagelijks leven van patiënten. Om deze invloed te verkleinen is het
niet alleen belangrijk om de ziekte goed te behandelen, maar ook om de ziekte in een vroeg stadium
te ontdekken. Dit is vooral van belang bij ziekten die het oog betreffen, omdat de cellen van het oog
weinig tot geen herstellend vermogen bezitten. Klinische parameters (bijv. leeftijd en
leefstijlfactoren) kunnen helpen om patiënten te identificeren met een verhoogd risico op ziekten en
complicaties, maar deze identificeren lang niet alle patiënten en zijn vaak niet specifiek voor de
ziekte. Dit benadrukt de behoefte aan biomarkers die gebruikt kunnen worden (in combinatie met
klinische parameters) om patiënten te identificeren met een verhoogd risico op specifieke ziekten en
complicaties.

Dit proefschrift beschrijft de rol van een opkomende groep van biomarkers, genaamd ‘advanced
glycation endproducts’ (AGEs), bij diabetes mellitus (suikerziekte) en bij netvliesloslating. AGEs
ontstaan gedurende chemische reacties waarbij versuikering en oxidatie optreedt van vrije
aminogroepen van eiwitten, vetten en nucleïnezuren. Het is aangetoond dat een verhoogde
stapeling van AGEs plaatsvindt in de weefsels van diabetes patiënten en in verschillende
celstructuren van het oog bij verscheidene oogziekten. AGEs kunnen niet-invasief gemeten worden
met behulp van de fluorescerende eigenschappen van verschillende AGEs. Deze techniek, ook wel
‘skin autofluorescence’ (SAF) genoemd, wordt gebruikt om de stapeling van AGEs in de huid te
meten.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Smit, Andries, Supervisor Hooymans, Anneke, Supervisor Mulder, Udo, Co-supervisor Los, Leonie, Co-supervisor
Datum van toekenning	13-nov-2017
Plaats van publicatie	[Groningen]
Uitgever	Rijksuniversiteit Groningen
Gedrukte ISBN's	978-94-034-0130-0
Elektronische ISBN's	978-94-034-0129-4
Status	Published - 2017

Toegang tot document

Title and contentsFinal publisher's version, 263 KB
Chapter 1Final publisher's version, 831 KB
Chapter 2Final publisher's version, 501 KB
Chapter 3Final publisher's version, 1,37 MB
Chapter 4Final publisher's version, 709 KB
Publisher version chapter 5Final publisher's version, 268 KB
Chapter 6Final publisher's version, 699 KB
Chapter 7Final publisher's version, 453 KB
Nederlandse samenvattingFinal publisher's version, 411 KB
DankwoordFinal publisher's version, 394 KB
Curriculum vitaeFinal publisher's version, 377 KB
BibliographyFinal publisher's version, 353 KB
PropositionsFinal publisher's version, 71,1 KB

Document onder embargo

Chapter 5
Final publisher's version, 762 KB
Embargo eindigt: 01/01/9999

Document onder embargo

Complete thesis
Final publisher's version, 2,57 MB
Embargo eindigt: 01/01/9999

Citeer dit

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title = "Diabetes mellitus and rhegmatogenous retinal detachment: Exploring the role of advanced glycation endproducts in systemic and local disease",

abstract = "Along with ageing of the population, the prevalence of many age related diseases is rising. Thetroublesome complications that accompany these diseases have a high impact on patients{\textquoteright} dailylive. To reduce this impact, it is not only important to treat the diseases well, but also to detect thediseases in an early stage. Especially, diseases that affect the eye, since the cells of the eye havelittle or no regenerative capacity. Clinical parameters can help to identify patients at higher riskof diseases and complications, but they are not sensitive and specific enough. This emphasizesthe need for new biomarkers that could be used (in addition to clinical parameters) to identifypatients at high risk of specific diseases and complications.This thesis addresses the role of an emerging group of biomarkers, called advanced glycationendproducts (AGEs), in diabetes mellitus (DM) and in rhegmatogenous retinal detachment (RRD). AGEs are formed during chemical processes in which free amino groups of proteins, lipids, and nucleic acids become glycated. Elevated levels of AGEs have been shown in tissues of diabetes patients and in several different cell structures of the eye in distinct ocular disorders. AGEs can be assessed non-invasively in the skin due to fluorescent properties of several AGEs. This technique, also referred to as skin autofluorescence (SAF), has been used to assess AGE accumulation in the skin.",

author = "Fokkens, {Bernardina Teunisje}",

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isbn = "978-94-034-0130-0",

publisher = "Rijksuniversiteit Groningen",

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N2 - Along with ageing of the population, the prevalence of many age related diseases is rising. Thetroublesome complications that accompany these diseases have a high impact on patients’ dailylive. To reduce this impact, it is not only important to treat the diseases well, but also to detect thediseases in an early stage. Especially, diseases that affect the eye, since the cells of the eye havelittle or no regenerative capacity. Clinical parameters can help to identify patients at higher riskof diseases and complications, but they are not sensitive and specific enough. This emphasizesthe need for new biomarkers that could be used (in addition to clinical parameters) to identifypatients at high risk of specific diseases and complications.This thesis addresses the role of an emerging group of biomarkers, called advanced glycationendproducts (AGEs), in diabetes mellitus (DM) and in rhegmatogenous retinal detachment (RRD). AGEs are formed during chemical processes in which free amino groups of proteins, lipids, and nucleic acids become glycated. Elevated levels of AGEs have been shown in tissues of diabetes patients and in several different cell structures of the eye in distinct ocular disorders. AGEs can be assessed non-invasively in the skin due to fluorescent properties of several AGEs. This technique, also referred to as skin autofluorescence (SAF), has been used to assess AGE accumulation in the skin.

AB - Along with ageing of the population, the prevalence of many age related diseases is rising. Thetroublesome complications that accompany these diseases have a high impact on patients’ dailylive. To reduce this impact, it is not only important to treat the diseases well, but also to detect thediseases in an early stage. Especially, diseases that affect the eye, since the cells of the eye havelittle or no regenerative capacity. Clinical parameters can help to identify patients at higher riskof diseases and complications, but they are not sensitive and specific enough. This emphasizesthe need for new biomarkers that could be used (in addition to clinical parameters) to identifypatients at high risk of specific diseases and complications.This thesis addresses the role of an emerging group of biomarkers, called advanced glycationendproducts (AGEs), in diabetes mellitus (DM) and in rhegmatogenous retinal detachment (RRD). AGEs are formed during chemical processes in which free amino groups of proteins, lipids, and nucleic acids become glycated. Elevated levels of AGEs have been shown in tissues of diabetes patients and in several different cell structures of the eye in distinct ocular disorders. AGEs can be assessed non-invasively in the skin due to fluorescent properties of several AGEs. This technique, also referred to as skin autofluorescence (SAF), has been used to assess AGE accumulation in the skin.

M3 - Thesis fully internal (DIV)

SN - 978-94-034-0130-0

PB - Rijksuniversiteit Groningen

CY - [Groningen]

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