Diagnosis, treatment and clinical perspectives of acromegaly

Ferdinand Roelfsema*, Gerrit van den Berg

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review


    Acromegaly is an insidious disease of the pituitary caused by a growth hormone-secreting adenoma. Generally, the diagnosis is made rather late in the course of the disease. Currently, acromegaly can be cured in about half of the patients with the disease by expert surgery. The remainder of non-surgically cured patients often can be effectively treated with somatostatin analogs; either with the new generation of dopaminergic drugs or with Pegvisomant, a GHreceptor blocking agent. However, at the time of diagnosis many patients suffer from serious comorbidities, including hypertension, heart disease, arthrosis, sleep apnea and diabetes mellitus. Recent reports have shown that mortality risk can be normalized. Nevertheless, all efforts should be undertaken to treat comorbidities. New strategies for surgery and medical treatment are discussed.

    Originele taal-2English
    Pagina's (van-tot)619-644
    Aantal pagina's26
    TijdschriftExpert review of endocrinology & metabolism
    Nummer van het tijdschrift6
    StatusPublished - 2015

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