Diagnostic avenues in (post-transplant) lymphoproliferative disorders

Filipe Montes de Jesus

doi:10.33612/diss.195399645

Diagnostic avenues in (post-transplant) lymphoproliferative disorders

Filipe Montes de Jesus

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The aim of this thesis was to investigate the role of imaging in the management of PTLD, with focus on [18F]FDG PET/CT. Additionally, we set out to explore new diagnostic methods with potential for clinical translation. In Part I (chapters 2-7), we reviewed the published literature on the role of different imaging modalities in PTLD and evaluated the diagnostic performance of [18F]FDG PET/CT for PTLD lesion detection in adults and children. Furthermore, we explored the role of [18F]FDG PET/CT semiquantification in PTLD for lesion classification and prognostication. In Part II (chapters 8-10) we proceeded to explore new avenues of research including: radiomics, identification of radiotracers adjunct to [18F]FDG and cfDNA analysis.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Glaudemans, Andor, Supervisor Dierckx, Rudi, Supervisor Kwee, Thomas, Co-supervisor Noordzij, Walter, Co-supervisor
Datum van toekenning	12-jan.-2022
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
DOI's	https://doi.org/10.33612/diss.195399645
Status	Published - 2022

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10.33612/diss.195399645

Title and contentsFinal publisher's version, 663 KB
Chapter 1Final publisher's version, 602 KB
Chapter 2Final publisher's version, 1,57 MB
Chapter 3Final publisher's version, 1,33 MB
Chapter 4Final publisher's version, 1,62 MB
Chapter 5Final publisher's version, 1,23 MB
Chapter 6Final publisher's version, 949 KB
Chapter 7Final publisher's version, 1,1 MB
Chapter 8Final publisher's version, 1,68 MB
Chapter 9Final publisher's version, 3,14 MB
Chapter 10Final publisher's version, 2,29 MB
Chapter 11Final publisher's version, 990 KB
SummaryFinal publisher's version, 541 KB
Nederlandse SamenvattingFinal publisher's version, 541 KB
AcknowledgementsFinal publisher's version, 548 KB
Complete thesisFinal publisher's version, 11,5 MB
PropositionsFinal publisher's version, 73,4 KB

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title = "Diagnostic avenues in (post-transplant) lymphoproliferative disorders",

abstract = "The aim of this thesis was to investigate the role of imaging in the management of PTLD, with focus on [18F]FDG PET/CT. Additionally, we set out to explore new diagnostic methods with potential for clinical translation. In Part I (chapters 2-7), we reviewed the published literature on the role of different imaging modalities in PTLD and evaluated the diagnostic performance of [18F]FDG PET/CT for PTLD lesion detection in adults and children. Furthermore, we explored the role of [18F]FDG PET/CT semiquantification in PTLD for lesion classification and prognostication. In Part II (chapters 8-10) we proceeded to explore new avenues of research including: radiomics, identification of radiotracers adjunct to [18F]FDG and cfDNA analysis.",

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doi = "10.33612/diss.195399645",

language = "English",

publisher = "University of Groningen",

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AU - Montes de Jesus, Filipe

PY - 2022

Y1 - 2022

N2 - The aim of this thesis was to investigate the role of imaging in the management of PTLD, with focus on [18F]FDG PET/CT. Additionally, we set out to explore new diagnostic methods with potential for clinical translation. In Part I (chapters 2-7), we reviewed the published literature on the role of different imaging modalities in PTLD and evaluated the diagnostic performance of [18F]FDG PET/CT for PTLD lesion detection in adults and children. Furthermore, we explored the role of [18F]FDG PET/CT semiquantification in PTLD for lesion classification and prognostication. In Part II (chapters 8-10) we proceeded to explore new avenues of research including: radiomics, identification of radiotracers adjunct to [18F]FDG and cfDNA analysis.

AB - The aim of this thesis was to investigate the role of imaging in the management of PTLD, with focus on [18F]FDG PET/CT. Additionally, we set out to explore new diagnostic methods with potential for clinical translation. In Part I (chapters 2-7), we reviewed the published literature on the role of different imaging modalities in PTLD and evaluated the diagnostic performance of [18F]FDG PET/CT for PTLD lesion detection in adults and children. Furthermore, we explored the role of [18F]FDG PET/CT semiquantification in PTLD for lesion classification and prognostication. In Part II (chapters 8-10) we proceeded to explore new avenues of research including: radiomics, identification of radiotracers adjunct to [18F]FDG and cfDNA analysis.

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M3 - Thesis fully internal (DIV)

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ER -

Diagnostic avenues in (post-transplant) lymphoproliferative disorders

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