Diastereoselective C(sp3)-H acetoxylation of phosphoramidites.

Anirban Mondal; Vanda Dašková; Xiaobing Chen; Niklas O Thiel; Georgios Alachouzos; Ben L Feringa

doi:10.1039/d5cc00550g

Diastereoselective C(sp³)-H acetoxylation of phosphoramidites.

Anirban Mondal, Vanda Dašková, Xiaobing Chen, Niklas O Thiel, Georgios Alachouzos, Ben L Feringa^*

^*Corresponding author voor dit werk

Synthetische Organische Chemie

Onderzoeksoutput › Academic › peer review

1 Downloads (Pure)

Samenvatting

Chiral phosphines are important ligands in asymmetric catalysis, yet their potential as directing groups for asymmetric C-H activation remains unexplored due to the oxidative nature of these reactions. We present a Pd-catalysed, P(III)-directed diastereoselective acetoxylation of phosphoramidites, with DFT calculations elucidating their unique reactivity and supporting the proposed reaction mechanism.

Originele taal-2	English
Artikelnummer	d5cc00550g
Pagina's (van-tot)	6510-6513
Aantal pagina's	4
Tijdschrift	Chemical communications (Cambridge, England)
Volume	61
Nummer van het tijdschrift	35
Vroegere onlinedatum	7-apr.-2025
DOI's	https://doi.org/10.1039/d5cc00550g
Status	Published - 2-mei-2025

Toegang tot document

10.1039/d5cc00550gLicentie: CC BY

Diastereoselective C(sp3)-H acetoxylation of phosphoramidites.Proof, 818 KBLicentie: CC BY

Handle.net

Permanente koppeling

Citeer dit

@article{b76b07d6719f4c778b13c52d81de2bb8,

title = "Diastereoselective C(sp3)-H acetoxylation of phosphoramidites.",

abstract = "Chiral phosphines are important ligands in asymmetric catalysis, yet their potential as directing groups for asymmetric C-H activation remains unexplored due to the oxidative nature of these reactions. We present a Pd-catalysed, P(III)-directed diastereoselective acetoxylation of phosphoramidites, with DFT calculations elucidating their unique reactivity and supporting the proposed reaction mechanism.",

author = "Anirban Mondal and Vanda Da{\v s}kov{\'a} and Xiaobing Chen and Thiel, {Niklas O} and Georgios Alachouzos and Feringa, {Ben L}",

year = "2025",

month = may,

day = "2",

doi = "10.1039/d5cc00550g",

language = "English",

volume = "61",

pages = "6510--6513",

journal = "Chemical communications (Cambridge, England)",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "35",

}

TY - JOUR

T1 - Diastereoselective C(sp3)-H acetoxylation of phosphoramidites.

AU - Mondal, Anirban

AU - Dašková, Vanda

AU - Chen, Xiaobing

AU - Thiel, Niklas O

AU - Alachouzos, Georgios

AU - Feringa, Ben L

PY - 2025/5/2

Y1 - 2025/5/2

N2 - Chiral phosphines are important ligands in asymmetric catalysis, yet their potential as directing groups for asymmetric C-H activation remains unexplored due to the oxidative nature of these reactions. We present a Pd-catalysed, P(III)-directed diastereoselective acetoxylation of phosphoramidites, with DFT calculations elucidating their unique reactivity and supporting the proposed reaction mechanism.

AB - Chiral phosphines are important ligands in asymmetric catalysis, yet their potential as directing groups for asymmetric C-H activation remains unexplored due to the oxidative nature of these reactions. We present a Pd-catalysed, P(III)-directed diastereoselective acetoxylation of phosphoramidites, with DFT calculations elucidating their unique reactivity and supporting the proposed reaction mechanism.

U2 - 10.1039/d5cc00550g

DO - 10.1039/d5cc00550g

M3 - Article

C2 - 40189936

SN - 1359-7345

VL - 61

SP - 6510

EP - 6513

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 35

M1 - d5cc00550g

ER -