Dibenzothiazepine Based MCR Chemistry

Xiaofang Lei, Giasemi Angeli, Alexander Dömling, Constantinos G. Neochoritis*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

10 Downloads (Pure)


Privileged scaffolds which can unveil unknown territories of the chemical space are constantly prominent. As such, 1,5-dibenzothiazepines not only offer structural diversification but also a very unique binding mode due to their “butterfly” conformation. We provide MCR-based annulations of this scaffold towards three different tetracycles in a straightforward, two-step procedure. We synthesize a library of 30 tetracyclic 1,5-tetrazolo-, fused imidazo- and lactam-1,5-dibenzothiazepines with scalable and one-pot procedures. In addition, we obtained single crystal structures of certain derivatives, demonstrating the conformational behavior of the scaffold.

Originele taal-2English
Aantal pagina's5
TijdschriftEuropean Journal of Organic Chemistry
Nummer van het tijdschrift20
StatusPublished - 25-mei-2022

Citeer dit