Dibenzothiazepine Based MCR Chemistry

Xiaofang Lei, Giasemi Angeli, Alexander Dömling, Constantinos G. Neochoritis*

*Bijbehorende auteur voor dit werk

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Samenvatting

Privileged scaffolds which can unveil unknown territories of the chemical space are constantly prominent. As such, 1,5-dibenzothiazepines not only offer structural diversification but also a very unique binding mode due to their “butterfly” conformation. We provide MCR-based annulations of this scaffold towards three different tetracycles in a straightforward, two-step procedure. We synthesize a library of 30 tetracyclic 1,5-tetrazolo-, fused imidazo- and lactam-1,5-dibenzothiazepines with scalable and one-pot procedures. In addition, we obtained single crystal structures of certain derivatives, demonstrating the conformational behavior of the scaffold.

Originele taal-2English
Artikelnummere202200220
Aantal pagina's5
TijdschriftEuropean Journal of Organic Chemistry
Volume2022
Nummer van het tijdschrift20
DOI's
StatusPublished - 25-mei-2022

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