Differential effects of 5-HTTLPR and DRD2/ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children

Monika Althaus; Yvonne Groen; Albertus A. Wijers; Lambertus J. M. Mulder; Ruud B. Minderaa; Ido P. Kema; Janneke D. A. Dijck; Catharina A. Hartman; Pieter J. Hoekstra

doi:10.1016/j.clinph.2008.10.012

Differential effects of 5-HTTLPR and DRD2/ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children

Monika Althaus^*, Yvonne Groen, Albertus A. Wijers, Lambertus J. M. Mulder, Ruud B. Minderaa, Ido P. Kema, Janneke D. A. Dijck, Catharina A. Hartman, Pieter J. Hoekstra

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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Objective: Applying a probabilistic learning task we examined the influence of functional polymorphisms of the serotonin transporter gene (5-HTTLPR) and the D2 dopamine receptor gene (DRD2/ANKK1) on error and feedback processing by measuring electrocortical event-related potentials (ERPs) in 10- to 12-year-old children.

Methods: Three pairwise group comparisons were conducted on four distinguishable ERP components, two of which were response-related, the other two feed back-related.

Results: Our ERP data revealed that children carrying the short (S) variant of the 5-HTTLPR gene process their errors more intensively while exhibiting less habituation to negative feedback with task progression compared to children who are homozygous for the 5-HTTLPR long (L) variant. Children possessing the Taq1 A variant of the DRD2 gene showed greater sensitivity to negative feedback and, as opposed to Taq1 A non-carriers, a diminishing sensitivity to positive feedback with task progression. Regarding error processing, children possessing both the S variant of the 5-HTTLPR and the Taq1 A allele of the DRD2 gene showed a picture quite similar to that of the 5-HTTLPR S carriers and regarding feedback processing quite similar to that of the DRD2 Taq1 A carriers.

Conclusions: Our findings support the hypotheses that the 5-HTTLPR S allele may predispose to (performance) anxiety, while DRD2 Taq1 A allele may predispose to the reward deficiency syndrome.

Significance: The results may further enhance our understanding of known associations between these polymorphisms and psychopathology. (C) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Originele taal-2	English
Pagina's (van-tot)	93-107
Aantal pagina's	15
Tijdschrift	Clinical Neurophysiology
Volume	120
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.clinph.2008.10.012
Status	Published - jan.-2009

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@article{e3f01c5811d74c998f6a8cb6e2e24112,

title = "Differential effects of 5-HTTLPR and DRD2/ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children",

abstract = "Objective: Applying a probabilistic learning task we examined the influence of functional polymorphisms of the serotonin transporter gene (5-HTTLPR) and the D2 dopamine receptor gene (DRD2/ANKK1) on error and feedback processing by measuring electrocortical event-related potentials (ERPs) in 10- to 12-year-old children.Methods: Three pairwise group comparisons were conducted on four distinguishable ERP components, two of which were response-related, the other two feed back-related.Results: Our ERP data revealed that children carrying the short (S) variant of the 5-HTTLPR gene process their errors more intensively while exhibiting less habituation to negative feedback with task progression compared to children who are homozygous for the 5-HTTLPR long (L) variant. Children possessing the Taq1 A variant of the DRD2 gene showed greater sensitivity to negative feedback and, as opposed to Taq1 A non-carriers, a diminishing sensitivity to positive feedback with task progression. Regarding error processing, children possessing both the S variant of the 5-HTTLPR and the Taq1 A allele of the DRD2 gene showed a picture quite similar to that of the 5-HTTLPR S carriers and regarding feedback processing quite similar to that of the DRD2 Taq1 A carriers.Conclusions: Our findings support the hypotheses that the 5-HTTLPR S allele may predispose to (performance) anxiety, while DRD2 Taq1 A allele may predispose to the reward deficiency syndrome.Significance: The results may further enhance our understanding of known associations between these polymorphisms and psychopathology. (C) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.",

keywords = "5-HTTLPR, DRD2/ANKK1, Performance monitoring, Error- and feedback-related ERPs, Performance anxiety, Reward deficiency syndrome, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, TRANSPORTER PROMOTER POLYMORPHISM, DOPAMINE-RECEPTOR GENE, SEROTONIN TRANSPORTER, BRAIN POTENTIALS, PERSONALITY-TRAITS, AUTISTIC DISORDER, ALLELIC VARIATION, DECISION-MAKING, HUMAN AMYGDALA",

author = "Monika Althaus and Yvonne Groen and Wijers, {Albertus A.} and Mulder, {Lambertus J. M.} and Minderaa, {Ruud B.} and Kema, {Ido P.} and Dijck, {Janneke D. A.} and Hartman, {Catharina A.} and Hoekstra, {Pieter J.}",

year = "2009",

month = jan,

doi = "10.1016/j.clinph.2008.10.012",

language = "English",

volume = "120",

pages = "93--107",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

publisher = "ELSEVIER IRELAND LTD",

number = "1",

}

TY - JOUR

T1 - Differential effects of 5-HTTLPR and DRD2/ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children

AU - Althaus, Monika

AU - Groen, Yvonne

AU - Wijers, Albertus A.

AU - Mulder, Lambertus J. M.

AU - Minderaa, Ruud B.

AU - Kema, Ido P.

AU - Dijck, Janneke D. A.

AU - Hartman, Catharina A.

AU - Hoekstra, Pieter J.

PY - 2009/1

Y1 - 2009/1

N2 - Objective: Applying a probabilistic learning task we examined the influence of functional polymorphisms of the serotonin transporter gene (5-HTTLPR) and the D2 dopamine receptor gene (DRD2/ANKK1) on error and feedback processing by measuring electrocortical event-related potentials (ERPs) in 10- to 12-year-old children.Methods: Three pairwise group comparisons were conducted on four distinguishable ERP components, two of which were response-related, the other two feed back-related.Results: Our ERP data revealed that children carrying the short (S) variant of the 5-HTTLPR gene process their errors more intensively while exhibiting less habituation to negative feedback with task progression compared to children who are homozygous for the 5-HTTLPR long (L) variant. Children possessing the Taq1 A variant of the DRD2 gene showed greater sensitivity to negative feedback and, as opposed to Taq1 A non-carriers, a diminishing sensitivity to positive feedback with task progression. Regarding error processing, children possessing both the S variant of the 5-HTTLPR and the Taq1 A allele of the DRD2 gene showed a picture quite similar to that of the 5-HTTLPR S carriers and regarding feedback processing quite similar to that of the DRD2 Taq1 A carriers.Conclusions: Our findings support the hypotheses that the 5-HTTLPR S allele may predispose to (performance) anxiety, while DRD2 Taq1 A allele may predispose to the reward deficiency syndrome.Significance: The results may further enhance our understanding of known associations between these polymorphisms and psychopathology. (C) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

AB - Objective: Applying a probabilistic learning task we examined the influence of functional polymorphisms of the serotonin transporter gene (5-HTTLPR) and the D2 dopamine receptor gene (DRD2/ANKK1) on error and feedback processing by measuring electrocortical event-related potentials (ERPs) in 10- to 12-year-old children.Methods: Three pairwise group comparisons were conducted on four distinguishable ERP components, two of which were response-related, the other two feed back-related.Results: Our ERP data revealed that children carrying the short (S) variant of the 5-HTTLPR gene process their errors more intensively while exhibiting less habituation to negative feedback with task progression compared to children who are homozygous for the 5-HTTLPR long (L) variant. Children possessing the Taq1 A variant of the DRD2 gene showed greater sensitivity to negative feedback and, as opposed to Taq1 A non-carriers, a diminishing sensitivity to positive feedback with task progression. Regarding error processing, children possessing both the S variant of the 5-HTTLPR and the Taq1 A allele of the DRD2 gene showed a picture quite similar to that of the 5-HTTLPR S carriers and regarding feedback processing quite similar to that of the DRD2 Taq1 A carriers.Conclusions: Our findings support the hypotheses that the 5-HTTLPR S allele may predispose to (performance) anxiety, while DRD2 Taq1 A allele may predispose to the reward deficiency syndrome.Significance: The results may further enhance our understanding of known associations between these polymorphisms and psychopathology. (C) 2008 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

KW - 5-HTTLPR

KW - DRD2/ANKK1

KW - Performance monitoring

KW - Error- and feedback-related ERPs

KW - Performance anxiety

KW - Reward deficiency syndrome

KW - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

KW - TRANSPORTER PROMOTER POLYMORPHISM

KW - DOPAMINE-RECEPTOR GENE

KW - SEROTONIN TRANSPORTER

KW - BRAIN POTENTIALS

KW - PERSONALITY-TRAITS

KW - AUTISTIC DISORDER

KW - ALLELIC VARIATION

KW - DECISION-MAKING

KW - HUMAN AMYGDALA

U2 - 10.1016/j.clinph.2008.10.012

DO - 10.1016/j.clinph.2008.10.012

M3 - Article

SN - 1388-2457

VL - 120

SP - 93

EP - 107

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 1

ER -

Differential effects of 5-HTTLPR and DRD2/ANKK1 polymorphisms on electrocortical measures of error and feedback processing in children

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