Diffusion tensor Imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy

P. E. Sijens*, Martinus Heesters, Roeline Enting, W. T. A. van der Graaf, J. H. Potze, Roy Irwan, L. C. Meiners, M. Oudkerk

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    17 Citaten (Scopus)


    Diffusion tensor imaging and multiple voxel magnetic resonance spectroscopy were performed in the MRI follow-up of a patient with a glioma treated with temozolomide chemotherapy. Tumor shrinkage was paralleled by reductions in choline level and by increases in apparent diffusion coefficient indicating decreased cellularity. Within the tumor, choline level and apparent diffusion coefficient showed a significant inverse correlation (P <0.01). Fractional anisotropy distribution in the tumor correlated positively with N-acetyl aspartate level (P <0.001), indicating that these parameters reflect (remaining) axonal structure. Tumor lactate level, also found to decrease under therapy, did not correlate with any other parameter.

    Originele taal-2English
    Pagina's (van-tot)706-710
    Aantal pagina's5
    TijdschriftCancer Investigation
    Nummer van het tijdschrift8
    StatusPublished - dec.-2007

    Citeer dit