Direct and Regioselective Di-alpha-fucosylation on the Secondary Rim of beta-Cyclodextrin

Stella A. Verkhnyatskaya, Alex H. de Vries, Elmatine Douma-de Vries, Enze J. L. Sneep, Marthe T. C. Walvoort*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)
232 Downloads (Pure)

Samenvatting

A straightforward glycosylation method is described to regio- and stereoselectively introduce two alpha-L-fucose moieties directly to the secondary rim of beta-cyclodextrin. Using NMR and MS fragmentation studies, the nonasaccharide structure was determined, which was also visualized using molecular dynamics simulations. The reported glycosylation method proved to be robust on gram-scale, and may be generally applied to directly glycosylate beta-cyclodextrins to make well-defined multivalent glycoclusters.

Originele taal-2English
Pagina's (van-tot)6722-6727
Aantal pagina's6
TijdschriftChemistry
Volume25
Nummer van het tijdschrift27
DOI's
StatusPublished - 10-mei-2019

Vingerafdruk

Duik in de onderzoeksthema's van 'Direct and Regioselective Di-alpha-fucosylation on the Secondary Rim of beta-Cyclodextrin'. Samen vormen ze een unieke vingerafdruk.

Citeer dit