Samenvatting
A straightforward glycosylation method is described to regio- and stereoselectively introduce two alpha-L-fucose moieties directly to the secondary rim of beta-cyclodextrin. Using NMR and MS fragmentation studies, the nonasaccharide structure was determined, which was also visualized using molecular dynamics simulations. The reported glycosylation method proved to be robust on gram-scale, and may be generally applied to directly glycosylate beta-cyclodextrins to make well-defined multivalent glycoclusters.
Originele taal-2 | English |
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Pagina's (van-tot) | 6722-6727 |
Aantal pagina's | 6 |
Tijdschrift | Chemistry |
Volume | 25 |
Nummer van het tijdschrift | 27 |
DOI's | |
Status | Published - 10-mei-2019 |