Directing Mesenchymal Stem Cells with Gold Nanowire Arrays

Qihui Zhou, Zhiyuan Zhao, Ziwei Zhou, Gang Zhang, Ryan C. Chiechi, Patrick van Rijn*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

15 Citaten (Scopus)

Samenvatting

Controlling cell organization is still a major bottleneck in biointerface engineering when the material dimensions decrease to the nanoscale. Here, Au nanowire-patterned array platforms with multiscale design from the macroscale to the nanoscale are developed for studying human bone marrow-derived mesenchymal stem cell (hBM-MSC) response. When the angle of the Au nanowires on glass is increased from 0 degrees to 90 degrees, hBM-MSC arrangement exhibits a transition from a unidirectional distribution induced by a vector response to a bimodal polarization pattern. The degree of cell vector response and elongation decreases with increasing nanowire angles from 0 degrees to 90 degrees. Further, it is demonstrated that the specific cell adhesion and organization are dependent on the surface micro/nanotopography, which is greatly enhanced by introducing stem cell-material affinity differences. An ideal model and new insights into a deeper understanding of cell-nano-biointerface interactions are provided.

Originele taal-2English
Artikelnummer1800334
Aantal pagina's8
TijdschriftAdvanced Materials Interfaces
Volume5
Nummer van het tijdschrift14
DOI's
StatusPublished - 23-jul-2018

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