Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Wenhao Jiang; Kelly Rootes-Murdy; Kuaikuai Duan; Gido Schoenmacker; Pieter J Hoekstra; Catharina A Hartman; Jaap Oosterlaan; Dirk Heslenfeld; Barbara Franke; Emma Sprooten; Jan Buitelaar; Alejandro Arias-Vasquez; Jingyu Liu; Jessica A Turner

doi:10.1016/j.pscychresns.2021.111282

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Wenhao Jiang, Kelly Rootes-Murdy^*, Kuaikuai Duan, Gido Schoenmacker, Pieter J Hoekstra, Catharina A Hartman, Jaap Oosterlaan, Dirk Heslenfeld, Barbara Franke, Emma Sprooten, Jan Buitelaar, Alejandro Arias-Vasquez, Jingyu Liu, Jessica A Turner

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

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A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Originele taal-2	English
Artikelnummer	111282
Aantal pagina's	4
Tijdschrift	Psychiatry research: Neuroimaging
Volume	311
DOI's	https://doi.org/10.1016/j.pscychresns.2021.111282
Status	Published - 30-mei-2021

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Jiang, W., Rootes-Murdy, K., Duan, K., Schoenmacker, G., Hoekstra, P. J., Hartman, C. A., Oosterlaan, J., Heslenfeld, D., Franke, B., Sprooten, E., Buitelaar, J., Arias-Vasquez, A., Liu, J., & Turner, J. A. (2021). Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD. Psychiatry research: Neuroimaging, 311, Artikel 111282. https://doi.org/10.1016/j.pscychresns.2021.111282

@article{0ca1268fb6394937a3d7f4a5504cce7d,

title = "Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD",

abstract = "A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.",

keywords = "ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, DEFICIT HYPERACTIVITY DISORDER, WORKING-MEMORY, RISK-FACTORS, CHILDREN, METAANALYSIS, PARTICIPANTS, CORTEX, VOLUME, MRI",

author = "Wenhao Jiang and Kelly Rootes-Murdy and Kuaikuai Duan and Gido Schoenmacker and Hoekstra, {Pieter J} and Hartman, {Catharina A} and Jaap Oosterlaan and Dirk Heslenfeld and Barbara Franke and Emma Sprooten and Jan Buitelaar and Alejandro Arias-Vasquez and Jingyu Liu and Turner, {Jessica A}",

note = "Copyright {\textcopyright} 2021. Published by Elsevier B.V.",

year = "2021",

month = may,

day = "30",

doi = "10.1016/j.pscychresns.2021.111282",

language = "English",

volume = "311",

journal = "Psychiatry research: Neuroimaging",

issn = "0925-4927",

publisher = "ELSEVIER IRELAND LTD",

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Jiang, W, Rootes-Murdy, K, Duan, K, Schoenmacker, G, Hoekstra, PJ , Hartman, CA, Oosterlaan, J, Heslenfeld, D, Franke, B, Sprooten, E, Buitelaar, J, Arias-Vasquez, A, Liu, J & Turner, JA 2021, 'Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD', Psychiatry research: Neuroimaging, vol. 311, 111282. https://doi.org/10.1016/j.pscychresns.2021.111282

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T1 - Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

AU - Jiang, Wenhao

AU - Rootes-Murdy, Kelly

AU - Duan, Kuaikuai

AU - Schoenmacker, Gido

AU - Hoekstra, Pieter J

AU - Hartman, Catharina A

AU - Oosterlaan, Jaap

AU - Heslenfeld, Dirk

AU - Franke, Barbara

AU - Sprooten, Emma

AU - Buitelaar, Jan

AU - Arias-Vasquez, Alejandro

AU - Liu, Jingyu

AU - Turner, Jessica A

PY - 2021/5/30

Y1 - 2021/5/30

N2 - A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

AB - A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

KW - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

KW - DEFICIT HYPERACTIVITY DISORDER

KW - WORKING-MEMORY

KW - RISK-FACTORS

KW - CHILDREN

KW - METAANALYSIS

KW - PARTICIPANTS

KW - CORTEX

KW - VOLUME

KW - MRI

U2 - 10.1016/j.pscychresns.2021.111282

DO - 10.1016/j.pscychresns.2021.111282

M3 - Article

C2 - 33780745

SN - 0925-4927

VL - 311

JO - Psychiatry research: Neuroimaging

JF - Psychiatry research: Neuroimaging

M1 - 111282

ER -

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

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