DJ-1 as a modulator of autophagy: an hypothesis

Rosa A González-Polo, Mireia Niso-Santano, Rubén Gómez-Sánchez, José M Bravo-San Pedro, José M Fuentes

OnderzoeksoutputAcademicpeer review

4 Citaten (Scopus)
45 Downloads (Pure)

Samenvatting

The etiology of Parkinson's disease (PD) is not completely defined, although environmental factors (for example, exposure to the herbicide paraquat [PQ]) and genetic susceptibility (such as DJ-1 mutations that have been associated with an autosomal-recessive form of early-onset PD) have been demonstrated to contribute. Alterations in macroautophagy have been described in the pathogenesis of this neurodegenerative disease. We have established a model system to study the involvement of the DJ-1 protein in PQ-induced autophagy. When we transfected cells exposed to PQ with DJ-1-specific siRNA, we observed an inhibition of the autophagic events induced by the herbicide, as well as sensitization additive with PQ-induced apoptotic cell death and exacerbation of this cell death in the presence of the autophagy inhibitor 3-methyladenine. These results suggest, for the first time, an active role for DJ-1 in the autophagic response produced by PQ, opening the door to new strategies for PD therapy.

Originele taal-2English
Pagina's (van-tot)1574-1579
Aantal pagina's6
TijdschriftThe Scientific World Journal
Volume10
DOI's
StatusPublished - 2010
Extern gepubliceerdJa

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