DNA-based hybrid catalysis

Ana Rioz-Martínez, Gerard Roelfes

OnderzoeksoutputAcademicpeer review

45 Citaten (Scopus)

Samenvatting

In the past decade, DNA-based hybrid catalysis has merged as a promising novel approach to homogeneous (asymmetric) catalysis. A DNA hybrid catalysts comprises a transition metal complex that is covalently or supramolecularly bound to DNA. The chiral microenvironment and the second coordination sphere interactions provided by the DNA are key to achieve high enantioselectivities and, often, additional rate accelerations in catalysis. Nowadays, current efforts are focused on improved designs, understanding the origin of the enantioselectivity and DNA-induced rate accelerations, expanding the catalytic scope of the concept and further increasing the practicality of the method for applications in synthesis. Herein, the recent developments will be reviewed and the perspectives for the emerging field of DNA-based hybrid catalysis will be discussed.

Originele taal-2English
Pagina's (van-tot)80-87
Aantal pagina's8
TijdschriftCurrent Opinion in Chemical Biology
Volume25
DOI's
StatusPublished - apr-2015

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