DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis

Arun Thiruvalluvan, Eduardo P. de Mattos, Jeanette F. Brunsting, Rob Bakels, Despina Serlidaki, Lara Barazzuol, Paola Conforti, Azra Fatima, Seda Koyuncu, Elena Cattaneo, David Vilchez, Steven Bergink, Erik H. W. G. Boddeke, Sjef Copray, Harm H. Kampinga*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

15 Citaten (Scopus)
18 Downloads (Pure)

Samenvatting

Thiruvalluvan et al. show that, upon differentiation, the cellular chaperone network is rewired. This includes a downregulation of the Hsp70 co-chaperone DNAJB6. High levels of DNAJB6 keep patient-derived neuronal progenitors resistant to the formation of amyloids. The sole knockdown of DNAJB6 in progenitors induces spontaneous aggregation of endogenously expressed polyglutamine proteins. Inversely, low levels of DNAJB6 in neurons render them hypersensitive to amyloid formation, which can be restored by re-elevating DNAJB6 expression levels.

Originele taal-2English
Pagina's (van-tot)346-+
Aantal pagina's22
TijdschriftMolecular Cell
Volume78
Nummer van het tijdschrift2
Vroegere onlinedatum2020
DOI's
StatusPublished - 16-apr-2020

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