Dopamine-functionalized polymers

Martin Franke Tooren (Uitvinder), Jacobus Antonius Loontjens (Uitvinder)

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The invention is directed to a tissue-adhesive polymer comprising at least one polymeric chain functionalized with an ArOH group, wherein said ArOH represents a hydroxyl-substituted aromatic group which is bound to said polymeric chain with an amide, urethane, thiourethane or urea bond, optionally Via a spacer. The ArOH can be positioned at one or more termini of said polymeric chain, at the backbone of the polymeric chain according to formula lb, or both. The ArOH can be based on a compound such as dopamine, DL-DOPA, L-DOPA, D-DOPA, tyramine, noradrenaline and/or serotonin. In addition, the invention is directed to a caprolactam blocked hydroxyl-substituted aromatic compound, suitable for the preparation of the tissue-adhesive polymer and to the method for the preparation of the tissue-adhesive polymer.
Originele taal-2English
OctrooinummerNL2023358
Prioriteitsdatum21/06/2019
Indieningsdatum21/06/2019
StatusPublished - 1-feb-2021

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