TY - JOUR
T1 - Driving Pressure During General Anesthesia for Open Abdominal Surgery (DESIGNATION)
T2 - study protocol of a randomized clinical trial
AU - DESIGNATION-Investigators
AU - Hol, Liselotte
AU - Hol, Liselotte
AU - Nijbroek, Sunny G. L. H.
AU - Neto, Ary Serpa
AU - de Abreu, Marcelo Gama
AU - Pelosi, Paolo
AU - Hemmes, Sabrine N. T.
AU - Aarts, Leon P. H. J.
AU - Akkerman, Ronald D. L.
AU - Albersen, Juliette J. E.
AU - Aurilio, Caterina
AU - Battaglini, Denise
AU - de Boer, Hans D.
AU - Boom, Annemieke
AU - Boer, Christa
AU - Brouwer, Tammo
AU - Buhre, Wolfgang F. F. A.
AU - Bulte, Carolina S. E.
AU - Edward-Rutten, Gitara M.
AU - Godfried, Marc B.
AU - Helmerhorst, Hendrik J. F.
AU - Hofland, Jan
AU - Hoogenboom, Hester
AU - Ten Hoope, W.
AU - Houweling, Bernard M.
AU - Huhn, Ragnar
AU - Konijn, Wanda
AU - Koopman-van Gemert, Ankie W. M. M.
AU - De Korte-de Boer, Dianne J.
AU - Kortekaas, Minke C.
AU - Van Lier, Felix
AU - Preckel, Benedikt
AU - Rad, Mandana
AU - Sansone, Pasquale
AU - Stamkot, Andre
AU - Stolker, Robert Jan
AU - Thiel, Bram
AU - Ubben, Johannes F. H.
AU - Struys, Michel M. R. F.
AU - In 't Veld, Bastiaan A.
AU - Wrigge, Hermann
AU - Zeillemaker-Hoekstra, Miriam
AU - van der Zwan, Tim
AU - Zwijsen, Johannes H. M. J.
AU - Hollmann, Markus W.
AU - Schultz, Marcus J.
PY - 2020/2/18
Y1 - 2020/2/18
N2 - Background Intraoperative driving pressure (Delta P) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (V-T) is kept constant, Delta P may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. Delta P may decrease if PEEP leads to a recruitment of collapsed lung tissue but will increase if PEEP mainly causes pulmonary overdistension. This study tests the hypothesis that individualized high PEEP, when compared to fixed low PEEP, protects against PPC in patients undergoing open abdominal surgery. Methods The "Driving prESsure durIng GeNeral AnesThesIa for Open abdomiNal surgery trial" (DESIGNATION) is an international, multicenter, two-group, double-blind randomized clinical superiority trial. A total of 1468 patients will be randomly assigned to one of the two intraoperative ventilation strategies. Investigators screen patients aged >= 18 years and with a body mass index
AB - Background Intraoperative driving pressure (Delta P) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (V-T) is kept constant, Delta P may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. Delta P may decrease if PEEP leads to a recruitment of collapsed lung tissue but will increase if PEEP mainly causes pulmonary overdistension. This study tests the hypothesis that individualized high PEEP, when compared to fixed low PEEP, protects against PPC in patients undergoing open abdominal surgery. Methods The "Driving prESsure durIng GeNeral AnesThesIa for Open abdomiNal surgery trial" (DESIGNATION) is an international, multicenter, two-group, double-blind randomized clinical superiority trial. A total of 1468 patients will be randomly assigned to one of the two intraoperative ventilation strategies. Investigators screen patients aged >= 18 years and with a body mass index
KW - Mechanical ventilation
KW - Intraoperative ventilation
KW - Delta P
KW - Compliance
KW - Positive end-expiratory pressure
KW - Recruitment maneuver
KW - Pulmonary complications
KW - Postoperative complications
KW - Postoperative pulmonary complications
KW - END-EXPIRATORY-PRESSURE
KW - POSTOPERATIVE PULMONARY COMPLICATIONS
KW - PROTECTIVE MECHANICAL VENTILATION
KW - CHEST-WALL MECHANICS
KW - LOW-TIDAL-VOLUME
KW - OBESE-PATIENTS
KW - LUNG
KW - ATELECTASIS
KW - DEFINITIONS
KW - PREVENTION
U2 - 10.1186/s13063-020-4075-z
DO - 10.1186/s13063-020-4075-z
M3 - Article
SN - 1745-6215
VL - 21
JO - Trials
JF - Trials
IS - 1
M1 - 198
ER -