Drugs mimicking calorie restriction and tools and methods for identifying the same

Cornelis Calkhoven (Uitvinder)



    The invention relates to the fields of medicine and drug development, more particularly to drugs that are capable of mimicking calorie restriction (CR), and to screening tools and screening methods for identifying the same. Provided is a dual reporter plasmid system comprising a first nucleic acid sequence encoding a Renilla luciferase transcript and a second nucleic acid sequence encoding a firefly luciferase transcript, wherein said nucleic acid sequences are both under control of the C/EBPβ-5'UTR-uORF. Also provided is adefovir or a prodrug thereof for use in a method for improving the metabolic health in a subject.
    Originele taal-2English
    StatusPublished - 26-apr-2018

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