Dynamic kinetic resolution process employing haloalkane dehalogenase

Alja Westerbeek, Wiktor Szymanski, Ben L. Feringa, Dick B. Janssen*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

16 Citaten (Scopus)
41 Downloads (Pure)

Samenvatting

The first dynamic kinetic resolution process with a haloalkane dehalogenase is described, allowing the efficient preparation of enantiopure alpha-hydroxyarnides from racemic alpha-bromoamides. A simple Membrane reactor is used to separate the enzyme from the nonsoluble, polymer based, and metal-free racemizing agent. A model substrate, N-pheny1-2-bromopropionamide, was converted to (S)-N-phenyl-2-hydroxypropionamide either with 63% yield and 95% e.e or with 78% yield and 88% e.e.

Originele taal-2English
Pagina's (van-tot)1654-1660
Aantal pagina's7
TijdschriftACS Catalysis
Volume1
Nummer van het tijdschrift12
DOI's
StatusPublished - dec-2011

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