Samenvatting
The data presented in this thesis call for: (1) global improvement in the identification of hypercholesterolemia in young individuals by using age- and gender-specific plasma LDL-c levels. These individuals have an increased lifetime risk of CVD – especially those suffering from FH – and personalized advice on lifestyle changes and cholesterol lowering medication should be considered; (2) promotion of the understanding and stimulation of using cardiovascular risk prevention guidelines; and (3) further studies to explore novel pathways implicated in disturbances of LDL metabolism as well as investigate genetic targets like STAP1 that ultimately could lead to improved diagnosis and treatment of dyslipidemia.
Originele taal-2 | English |
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Kwalificatie | Doctor of Philosophy |
Toekennende instantie |
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Begeleider(s)/adviseur |
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Datum van toekenning | 16-mei-2018 |
Plaats van publicatie | [Groningen] |
Uitgever | |
Gedrukte ISBN's | 978-94-034-0491-2 |
Elektronische ISBN's | 978-94-034-0490-5 |
Status | Published - 2018 |