Dyslipidemia in the Young: From Genotype to Treatment

Jan-Willem Balder

Dyslipidemia in the Young: From Genotype to Treatment

Jan-Willem Balder

Onderzoeksoutput: Thesis fully internal (DIV)

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The data presented in this thesis call for: (1) global improvement in the identification of hypercholesterolemia in young individuals by using age- and gender-specific plasma LDL-c levels. These individuals have an increased lifetime risk of CVD – especially those suffering from FH – and personalized advice on lifestyle changes and cholesterol lowering medication should be considered; (2) promotion of the understanding and stimulation of using cardiovascular risk prevention guidelines; and (3) further studies to explore novel pathways implicated in disturbances of LDL metabolism as well as investigate genetic targets like STAP1 that ultimately could lead to improved diagnosis and treatment of dyslipidemia.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Kuivenhoven, Jan Albert, Supervisor Kamphuisen, Thomas, Supervisor van de Sluis, Bart, Supervisor
Datum van toekenning	16-mei-2018
Plaats van publicatie	[Groningen]
Uitgever	Rijksuniversiteit Groningen
Gedrukte ISBN's	978-94-034-0491-2
Elektronische ISBN's	978-94-034-0490-5
Status	Published - 2018

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Title and contentsFinal publisher's version, 4,09 MB
Chapter 1Final publisher's version, 8,42 MB
Chapter 2Final publisher's version, 8,53 MB
Chapter 3Final publisher's version, 8,5 MB
Chapter 4Final publisher's version, 9,28 MB
Chapter 5Final publisher's version, 9,26 MB
Chapter 6Final publisher's version, 9,19 MB
Chapter 7Final publisher's version, 9,64 MB
Chapter 8Final publisher's version, 13 MB
Chapter 9Final publisher's version, 8,42 MB
AddendumFinal publisher's version, 4,61 MB
Complete thesisFinal publisher's version, 92,5 MB
PropositionsFinal publisher's version, 2,8 MB

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N2 - The data presented in this thesis call for: (1) global improvement in the identification of hypercholesterolemia in young individuals by using age- and gender-specific plasma LDL-c levels. These individuals have an increased lifetime risk of CVD – especially those suffering from FH – and personalized advice on lifestyle changes and cholesterol lowering medication should be considered; (2) promotion of the understanding and stimulation of using cardiovascular risk prevention guidelines; and (3) further studies to explore novel pathways implicated in disturbances of LDL metabolism as well as investigate genetic targets like STAP1 that ultimately could lead to improved diagnosis and treatment of dyslipidemia.

AB - The data presented in this thesis call for: (1) global improvement in the identification of hypercholesterolemia in young individuals by using age- and gender-specific plasma LDL-c levels. These individuals have an increased lifetime risk of CVD – especially those suffering from FH – and personalized advice on lifestyle changes and cholesterol lowering medication should be considered; (2) promotion of the understanding and stimulation of using cardiovascular risk prevention guidelines; and (3) further studies to explore novel pathways implicated in disturbances of LDL metabolism as well as investigate genetic targets like STAP1 that ultimately could lead to improved diagnosis and treatment of dyslipidemia.

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