Dyslipidemia in the Young: From Genotype to Treatment

Jan-Willem Balder

    Onderzoeksoutput: Thesis fully internal (DIV)

    1083 Downloads (Pure)


    The data presented in this thesis call for: (1) global improvement in the identification of hypercholesterolemia in young individuals by using age- and gender-specific plasma LDL-c levels. These individuals have an increased lifetime risk of CVD – especially those suffering from FH – and personalized advice on lifestyle changes and cholesterol lowering medication should be considered; (2) promotion of the understanding and stimulation of using cardiovascular risk prevention guidelines; and (3) further studies to explore novel pathways implicated in disturbances of LDL metabolism as well as investigate genetic targets like STAP1 that ultimately could lead to improved diagnosis and treatment of dyslipidemia.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    • Kuivenhoven, Jan Albert, Supervisor
    • Kamphuisen, Thomas, Supervisor
    • van de Sluis, Bart, Supervisor
    Datum van toekenning16-mei-2018
    Plaats van publicatie[Groningen]
    Gedrukte ISBN's978-94-034-0491-2
    Elektronische ISBN's978-94-034-0490-5
    StatusPublished - 2018

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