Early corticosteroid treatment does not affect severity of unconjugated hyperbilirubinemia in extreme low birth weight preterm infants

Christian V. Hulzebos*, Arend F. Bos, Eija Anttila, Mikko Hallman, Henkjan J. Verkade

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)


Aim: To determine the relationship between early postnatal dexamethasone (DXM) treatment and the severity of hyperbilirubinemia in extreme low birth weight (ELBW) preterm infants.

Methods: In 54 ELBW preterm infants, total serum bilirubin concentrations (TSB) and phototherapy (PT) data during the first 10 days were evaluated retrospectively. ELBW infants had participated in a randomized controlled trial of early DXM treatment which aimed to assess effects on chronic lung disease. Infants had been treated with DXM (0.25 mg/kg twice daily at postnatal day 1 and 2) or with placebo (normal saline). Analysis was performed on an intention to treat basis.

Results: Twenty-five Infants had been randomized into the DXM group; 29 into the placebo group. Mean (+/- SD) TSB [120 (+/- 19) mu mol/L vs. 123 (+/- 28) mu mol/L, DXM versus placebo, respectively] and maximum TSB [178 (+/- 23) mu mol/L vs. 176 (+/- 48), DXM versus placebo, respectively] concentrations were similar. TSB concentrations peaked 30 h earlier in the DXM group (p

Conclusions: Early DXM treatment does not affect the severity of neonatal hyperbilirubinemia in ELBW preterm infants. Our results seem compatible with the concept that factors other than bilirubin conjugation capacity are important for the pathophysiology of neonatal jaundice in ELBW preterm infants.

Originele taal-2English
Pagina's (van-tot)170-174
Aantal pagina's5
TijdschriftActa Paediatrica
Nummer van het tijdschrift2
StatusPublished - feb-2011

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