Early lactate and glucose kinetics following return to spontaneous circulation after out-of-hospital cardiac arrest

Pedro Freire Jorge*, Rohan Boer, Rene A Posma, Katharina C Harms, Bart Hiemstra, Bas W J Bens, Maarten W Nijsten

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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OBJECTIVE: Lactate has been shown to be preferentially metabolized in comparison to glucose after physiological stress, such as strenuous exercise. Derangements of lactate and glucose are common after out-of-hospital cardiac arrest (OHCA). Therefore, we hypothesized that lactate decreases faster than glucose after return-to-spontaneous-circulation (ROSC) after OHCA.

RESULTS: We included 155 OHCA patients in our analysis. Within the first 8 h of presentation to the emergency department, 843 lactates and 1019 glucoses were available, respectively. Lactate decreased to 50% of its initial value within 1.5 h (95% CI [0.2-3.6 h]), while glucose halved within 5.6 h (95% CI [5.4-5.7 h]). Also, in the first 8 h after presentation lactate decreases more than glucose in relation to their initial values (lactate 72.6% vs glucose 52.1%). In patients with marked hyperlactatemia after OHCA, lactate decreased expediently while glucose recovered more slowly, whereas arterial pH recovered at a similar rapid rate as lactate. Hospital non-survivors (N = 82) had a slower recovery of lactate (P = 0.002) than survivors (N = 82). The preferential clearance of lactate underscores its role as a prime energy substrate, when available, during recovery from extreme stress.

Originele taal-2English
Aantal pagina's7
TijdschriftBMC Research Notes
Nummer van het tijdschrift1
StatusPublished - 13-mei-2021

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