Samenvatting
External control of bacterial communication—quorum sensing—allows for the
regulation of a multitude of biological processes. Herein, we describe the development of a new synthetic methodology, as well as the characterization, photoisomerization, and biological evaluation of a privileged series of novel photoswitchable quorum-sensing agonists and antagonists. The presented method allows for the rapid and convenient synthesis of previously unknown photoswitchable agonists with up to 70% quorum-sensing induction and inhibitors reaching up to 40% inhibition, which significantly extends the level of photocontrol over bacterial communication achieved before. Remarkably, for the lead photoswitchable agonist, a >700-fold difference in activity was observed between the irradiated and non-irradiated forms, which allows for antagonism to -agonism switching upon exposure to light, showing levels of control unprecedented in photopharmacology. Finally, utilizing this system, we were able to regulate toxin production in Pseudomonas aeruginosa with light.
Originele taal-2 | English |
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Pagina's (van-tot) | 1293-1301 |
Tijdschrift | Chem |
Volume | 5 |
Nummer van het tijdschrift | 5 |
DOI's | |
Status | Published - 15-apr.-2019 |
Vingerafdruk
Duik in de onderzoeksthema's van 'Easily Accessible, Highly Potent, Photocontrolled Modulators of Bacterial Communication'. Samen vormen ze een unieke vingerafdruk.Pers/Media
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Bacteriën te controleren met lichtgevoelige schakelaar
15/04/2019
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Pers / media: Activiteiten met een maatschappelijk belang › Academic