Echogenicity of Dupuytren's nodules is correlated to myofibroblast load and nodule hardness

Sanne Molenkamp*, Whangzao Song, Marjolein Bloembergen, Dieuwke C. Broekstra, Paul M. N. Werker

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

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Samenvatting

This study aimed to determine the association between the echogenicity of Dupuytren's disease nodules and myofibroblast load, and between echogenicity and nodule hardness. Thirty-eight nodules were assessed sonographically. The echogenicity of nodules was measured objectively with Image J (grey-value) and subjectively by visual inspection (hypo-, mixed and hyper-echogenicity). These findings were compared with myofibroblast load measured by histopathological analysis. In a different cohort, 97 nodules were assessed for grey-value and nodule hardness using a tonometer. There was a moderate, significant, negative association between grey-value and myofibroblast load and the subjective visual measurements corresponded to this finding. There was also a moderate, significant, negative association between grey-value and nodule hardness. Ultrasound and tonometry may be useful in the selection of patients for possible future preventive treatments.

Originele taal-2English
Pagina's (van-tot)280-287
Aantal pagina's8
TijdschriftJournal of Hand Surgery (European volume)
Volume47
Nummer van het tijdschrift3
Vroegere onlinedatum7-okt-2021
DOI's
StatusPublished - 1-mrt-2022

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