Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non-Cystic Fibrosis Bronchiectasis The BAT Randomized Controlled Trial

Josje Altenburg*, Casper S. de Graaff, Ymkje Stienstra, Jacobus H. Sloos, Eric H. J. van Haren, Ralph J. H. Koppers, Tjip S. van der Werf, Wim G. Boersma

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

317 Citaten (Scopus)

Samenvatting

Importance Macrolide antibiotics have been shown beneficial in cystic fibrosis (CF) and diffuse panbronchiolitis, and earlier findings also suggest a benefit in non-CF bronchiectasis.

Objective To determine the efficacy of macrolide maintenance treatment for adults with non-CF bronchiectasis.

Design, Setting, and Participants The BAT (Bronchiectasis and Long-term Azithromycin Treatment) study, a randomized, double-blind, placebo-controlled trial conducted between April 2008 and September 2010 in 14 hospitals in the Netherlands among 83 outpatients with non-CF bronchiectasis and 3 or more lower respiratory tract infections in the preceding year.

Interventions Azithromycin (250 mg daily) or placebo for 12 months.

Main Outcome Measures Number of infectious exacerbations during 12 months of treatment. Secondary end points included lung function, sputum bacteriology, inflammatory markers, adverse effects, symptom scores, and quality of life.

Results Forty-three participants (52%) received azithromycin and 40 (48%) received placebo and were included in the modified intention-to-treat analysis. At end of study, the median number of exacerbations in the azithromycin group was 0 (interquartile range [IQR], 0-1), compared with 2 (IQR, 1-3) in the placebo group (P

Conclusions and Relevance Among adults with non-CF bronchiectasis, the daily use of azithromycin for 12 months compared with placebo resulted in a lower rate of infectious exacerbations. This could result in better quality of life and might influence survival, although effects on antibiotic resistance need to be considered.

Originele taal-2English
Pagina's (van-tot)1251-1259
Aantal pagina's9
TijdschriftJournal of the American Medical Association
Volume309
Nummer van het tijdschrift12
StatusPublished - 27-mrt-2013

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