Effect of Caloric Restriction on Myocardial Fatty Acid Uptake, Left Ventricular Mass, and Cardiac Work in Obese Adults

Antti P. M. Viljanen*, Anna Karmi, Ronald Borra, Jussi P. Parkka, Virva Lepomaki, Riitta Parkkola, Riikka Lautamaki, Mikko Jarvisalo, Markku Taittonen, Tapani Ronnemaa, Patricia Iozzo, Juhani Knuuti, Pirjo Nuutila, Olli T. Raitakari

*Corresponding author voor dit werk

    OnderzoeksoutputAcademicpeer review

    66 Citaten (Scopus)

    Samenvatting

    Obesity is associated with increased fatty acid uptake in the myocardium, and this may have deleterious effects on cardiac function. The aim of this study was to evaluate how weight loss influences myocardial metabolism and cardiac work in obese adults. Thirty-four obese (mean body mass index 33.7 +/- 0.7 kg/m(2)) but otherwise healthy subjects consumed a very low calorie diet for 6 weeks. Cardiac substrate metabolism and work were measured before and after the diet. Myocardial fatty acid uptake was measured in 18 subjects using fluorine-18-fluoro-6-thia-heptadecanoic acid and positron emission tomography, and myocardial glucose uptake was measured in 16 subjects using fluorine-18-2-fluoro-2-deoxyglucose. Myocardial structure and cardiac function were measured using magnetic resonance imaging. Consumption of the very low calorie diet decreased weight (-11.2 +/- 0.6 kg, p

    Originele taal-2English
    Pagina's (van-tot)1721-1726
    Aantal pagina's6
    TijdschriftAmerican Journal of Cardiology
    Volume103
    Nummer van het tijdschrift12
    DOI's
    StatusPublished - 15-jun.-2009

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