Effect of Roux-en-Y gastric bypass on the bioavailability of metoprolol from immediate and controlled release tablets: A single oral dose study before and after surgery

Jan Peter Yska*, Jacquelien T. M. Wanders, Blessing Odigie, Jan A Apers, Marloes Emous, Erik R. E. Totté, E Christiaan Boerma, Froukje L. Ubels, Herman J. Woerdenbag, Henderik W. Frijlink, Bob Wilffert, Eric N. Van Roon

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

6 Citaten (Scopus)
98 Downloads (Pure)

Samenvatting

Objective Roux-en-Y gastric bypass (RYGB) surgery induces major changes in the gastrointestinal tract that may alter the pharmacokinetics of orally administered drugs. Results from pharmacokinetic studies are sparse. This study aimed to investigate the effect of RYGB on the bioavailability of metoprolol from immediate release (IR) and controlled release (CR) tablets in female patient volunteers before and after surgery.

Methods An explorative, two-phase, single oral dose pharmacokinetic study of metoprolol in female patients undergoing RYGB was carried out. The dose was administered twice in each patient, 1month before and 6months after surgery. After intake of either 100mg of metoprolol IR or CR tablet serum concentration-time profiles of metoprolol were determined. The endpoint was the ratio of AUC(after)/AUC(before) of metoprolol.

Results Twelve patients were included in the study (metoprolol IR: 7; metoprolol CR: 5). After intake of a metoprolol IR tablet major intraindividual and interindividual differences for area under the serum concentration versus time curve (AUC) of metoprolol before and after surgery were observed (range ratio AUC(0-10 hours after)/AUC(0-10 hours before): 0.74-1.98). For metoprolol CR tablets a significant reduction in bioavailability of metoprolol was observed after surgery (range ratio AUC(0-24 hours after)/AUC(0-24 hours before): 0.43-0.77).

Conclusion RYGB may influence the bioavailability of metoprolol from an IR tablet. The magnitude of changes in bioavailability after RYGB requires close monitoring of patients using metoprolol IR tablets and dose adjustment if deemed necessary. RYGB clearly reduces the bioavailability of metoprolol from a CR tablet. After RYGB clinicians may consider to increase the dose according to clinical response.

Originele taal-2English
Pagina's (van-tot)e19–e24
Aantal pagina's6
TijdschriftEuropean Journal of Hospital Pharmacy: Science and Practice
Volume27
Nummer van het tijdschriftE1
DOI's
StatusPublished - mrt.-2020

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