Effects of bilateral prefrontal rTMS on brain activation during social - emotional evaluation in schizophrenia: A double-blind, randomized, exploratory study

Edith J. Liemburg; Jozarni J. Dlabac-De Lange; Leonie Bais; Henderikus Knegtering; Andre Aleman

doi:10.1016/j.schres.2018.06.051

Effects of bilateral prefrontal rTMS on brain activation during social - emotional evaluation in schizophrenia: A double-blind, randomized, exploratory study

Edith J. Liemburg^*, Jozarni J. Dlabac-De Lange, Leonie Bais, Henderikus Knegtering, Andre Aleman

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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This exploratory study reports on the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on (prefrontal) brain activity changes during ambiguous emotional evaluation in patients with schizophrenia. Before and after randomly assigned treatment with active and sham rTMS, patients performed the Wall of Faces task during fMRI scanning. fMRI analysis showed that rTMS treatment resulted in reduced activation of striato-fronto-parietal brain areas, while activation increased compared to baseline after sham. Thus, prefrontal rIMS may normalize an increased brain response to ambiguous emotional stimuli, but future studies should confirm these findings. (C) 2018 Elsevier B.V. All rights reserved.

Originele taal-2	English
Pagina's (van-tot)	210-211
Aantal pagina's	2
Tijdschrift	Schizophrenia Research
Volume	202
DOI's	https://doi.org/10.1016/j.schres.2018.06.051
Status	Published - dec.-2018

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10.1016/j.schres.2018.06.051

Effects of bilateral prefrontal rTMS on brain activation during social-emotional evaluationFinal publisher's version, 363 KBLicentie: Taverne

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@article{5371ec597ad14abd98b09e76cdcb6c09,

title = "Effects of bilateral prefrontal rTMS on brain activation during social - emotional evaluation in schizophrenia: A double-blind, randomized, exploratory study",

abstract = "This exploratory study reports on the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on (prefrontal) brain activity changes during ambiguous emotional evaluation in patients with schizophrenia. Before and after randomly assigned treatment with active and sham rTMS, patients performed the Wall of Faces task during fMRI scanning. fMRI analysis showed that rTMS treatment resulted in reduced activation of striato-fronto-parietal brain areas, while activation increased compared to baseline after sham. Thus, prefrontal rIMS may normalize an increased brain response to ambiguous emotional stimuli, but future studies should confirm these findings. (C) 2018 Elsevier B.V. All rights reserved.",

keywords = "fMRI, Negative symptoms, rTMS, Schizophrenia, Social-emotional, TRANSCRANIAL MAGNETIC STIMULATION, NEGATIVE SYMPTOMS, WORKING-MEMORY",

author = "Liemburg, {Edith J.} and {Dlabac-De Lange}, {Jozarni J.} and Leonie Bais and Henderikus Knegtering and Andre Aleman",

year = "2018",

month = dec,

doi = "10.1016/j.schres.2018.06.051",

language = "English",

volume = "202",

pages = "210--211",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "ELSEVIER SCIENCE BV",

}

TY - JOUR

T1 - Effects of bilateral prefrontal rTMS on brain activation during social - emotional evaluation in schizophrenia

T2 - A double-blind, randomized, exploratory study

AU - Liemburg, Edith J.

AU - Dlabac-De Lange, Jozarni J.

AU - Bais, Leonie

AU - Knegtering, Henderikus

AU - Aleman, Andre

PY - 2018/12

Y1 - 2018/12

N2 - This exploratory study reports on the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on (prefrontal) brain activity changes during ambiguous emotional evaluation in patients with schizophrenia. Before and after randomly assigned treatment with active and sham rTMS, patients performed the Wall of Faces task during fMRI scanning. fMRI analysis showed that rTMS treatment resulted in reduced activation of striato-fronto-parietal brain areas, while activation increased compared to baseline after sham. Thus, prefrontal rIMS may normalize an increased brain response to ambiguous emotional stimuli, but future studies should confirm these findings. (C) 2018 Elsevier B.V. All rights reserved.

AB - This exploratory study reports on the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on (prefrontal) brain activity changes during ambiguous emotional evaluation in patients with schizophrenia. Before and after randomly assigned treatment with active and sham rTMS, patients performed the Wall of Faces task during fMRI scanning. fMRI analysis showed that rTMS treatment resulted in reduced activation of striato-fronto-parietal brain areas, while activation increased compared to baseline after sham. Thus, prefrontal rIMS may normalize an increased brain response to ambiguous emotional stimuli, but future studies should confirm these findings. (C) 2018 Elsevier B.V. All rights reserved.

KW - fMRI

KW - Negative symptoms

KW - rTMS

KW - Schizophrenia

KW - Social-emotional

KW - TRANSCRANIAL MAGNETIC STIMULATION

KW - NEGATIVE SYMPTOMS

KW - WORKING-MEMORY

U2 - 10.1016/j.schres.2018.06.051

DO - 10.1016/j.schres.2018.06.051

M3 - Article

SN - 0920-9964

VL - 202

SP - 210

EP - 211

JO - Schizophrenia Research

JF - Schizophrenia Research

ER -

Effects of bilateral prefrontal rTMS on brain activation during social - emotional evaluation in schizophrenia: A double-blind, randomized, exploratory study

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